Precision Medicine

A Knowledge-Enhanced Platform (MetaSepsisKnowHub) for Retrieval Augmented Generation–Based Sepsis Heterogeneity and Personalized Management: Development Study

Chi Zhang, Hao Yang, Xingyun Liu, Rongrong Wu, Hui Zong, Erman Wu, Yi Zhou, Jiakun Li, Bairong Shen

J Med Internet Res 2025 (Jun 06); 27:e67201

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Big Data–Driven Health Portraits for Personalized Management in Noncommunicable Diseases: Scoping Review

Haoyang Du, Jianing Yu, Dandan Chen, Jingjie Wu, Erxu Xue, Yufeng Zhou, Xiaohua Pan, Jing Shao, Zhihong Ye

J Med Internet Res 2025 (Jun 05); 27:e72636

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Data Inaccessibility Is Stifling the Digital Twin Implementation in Health Care

Md Doulotuzzaman Xames

J Med Internet Res 2025 (Jun 03); 27:e76524

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Understanding Gender-Specific Daily Care Preferences: Topic Modeling Study

Kyungmi Woo, Se Hee Min, Aeri Kim, Subin Choi, Gregory L Alexander, Terrence O’Malley, Maria D Moen, Maxim Topaz

J Med Internet Res 2025 (May 29); 27:e64160

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ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Controlled Trial

Thomas M Deutsch, Léa L Volmer, Manuel Feisst, Laura Bodenbeck, Kathrin Hassdenteufel, Lara Tretschock, Christiane Breit, Stefan Stefanovic, Armin Bauer, Carolin Anders, Lina Weinert, Tobias Engler, Andreas D Hartkopf, Nico Pfeifer, Pascal Escher, Marc Mausch, Oliver Heinze, Marc Suetterlin, Sara Y Brucker, Andreas Schneeweiss, Markus Wallwiener

JMIR Res Protoc 2025 (May 26); 14:e69855

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Immunogenicity of COVID-19 Vaccination in Immunocompromised Patients (Auto-COVID-VACC): Protocol for Multicenter Prospective Noninterventional Study

Louise Marie Cremer, Ullrich Bethe, Peter Borchmann, Veronica Di Cristanziano, Lutz Gieselmann, Sarah Grimm, Martin Hellmich, Julia Jakobs, Julia A Nacov, Julia M Neuhann, Juergen Prattes, Christoph Scheid, Rosanne Sprute, Gertrud Steger, Jannik Stemler, Sibylle C Mellinghoff, Oliver A Cornely

JMIR Res Protoc 2025 (May 26); 14:e60675

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Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study

Ken Nagino, Yasutsugu Akasaki, Nobuo Fuse, Soichi Ogishima, Atsushi Shimizu, Akira Uruno, Yoichi Sutoh, Yayoi Otsuka-Yamasaki, Fuji Nagami, Jun Seita, Tomohiro Nakamura, Satoshi Nagaie, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Atsuko Eguchi, Akie Midorikawa-Inomata, Masahiro Nakamura, Akira Murakami, Shintaro Nakao, Takenori Inomata

JMIR Res Protoc 2025 (May 12); 14:e67862

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Forecasting Subjective Cognitive Decline: AI Approach Using Dynamic Bayesian Networks

Antti Etholén, Teemu Roos, Mirja Hänninen, Ioanna Bouri, Jenni Kulmala, Ossi Rahkonen, Anne Kouvonen, Tea Lallukka

J Med Internet Res 2025 (May 06); 27:e65028

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Trust and Privacy Concerns Among Cancer Survivors Who Did Not Visit a Research Website Offering Free Genetic Counseling Services for Families: Survey Study

James A Shepperd, Colleen M McBride, Weihua An, Jingsong Zhao, Rebecca D Pentz, Cam Escoffery, Kevin Ward, Yue Guan

J Med Internet Res 2025 (May 06); 27:e64228

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The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study

An Tuan Huynh, Hoang Anh Vu, Ho Quoc Chuong, Tien Hoang Anh, An Viet Tran

JMIR Cardio 2025 (May 01); 9:e71016

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Survival Tree Analysis of Interactions Among Factors Associated With Colorectal Cancer Risk in Patients With Type 2 Diabetes: Retrospective Cohort Study

Sarah Tsz Yui Yau, Chi Tim Hung, Eman Yee Man Leung, Albert Lee, Eng Kiong Yeoh

JMIR Public Health Surveill 2025 (Apr 29); 11:e62756

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Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Andrew Hooyman, Matt J Huentelman, Matt De Both, Lee Ryan, Kevin Duff, Sydney Y Schaefer

JMIR Aging 2025 (Apr 24); 8:e67298

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Advancing Emergency Care With Digital Twins

Haoran Li, Jingya Zhang, Ning Zhang, Bin Zhu

JMIR Aging 2025 (Apr 21); 8:e71777

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AI-Derived Blood Biomarkers for Ovarian Cancer Diagnosis: Systematic Review and Meta-Analysis

He-Li Xu, Xiao-Ying Li, Ming-Qian Jia, Qi-Peng Ma, Ying-Hua Zhang, Fang-Hua Liu, Ying Qin, Yu-Han Chen, Yu Li, Xi-Yang Chen, Yi-Lin Xu, Dong-Run Li, Dong-Dong Wang, Dong-Hui Huang, Qian Xiao, Yu-Hong Zhao, Song Gao, Xue Qin, Tao Tao, Ting-Ting Gong, Qi-Jun Wu

J Med Internet Res 2025 (Mar 24); 27:e67922

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A Hybrid Deep Learning–Based Feature Selection Approach for Supporting Early Detection of Long-Term Behavioral Outcomes in Survivors of Cancer: Cross-Sectional Study

Tracy Huang, Chun-Kit Ngan, Yin Ting Cheung, Madelyn Marcotte, Benjamin Cabrera

JMIR Bioinform Biotech 2025 (Mar 13); 6:e65001

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Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025 (Mar 10); 14:e44027

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FRAILSURVEY—an mHealth App for Self-Assessment of Frailty Based on the Portuguese Version of the Groningen Frailty Indicator: Validation and Reliability Study

Luis Midao, Mafalda Duarte, Rute Sampaio, Marta Almada, Cláudia Camila Dias, Constança Paúl, Elísio Costa

JMIR Form Res 2025 (Mar 07); 9:e51975

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Retrieval Augmented Therapy Suggestion for Molecular Tumor Boards: Algorithmic Development and Validation Study

Eliza Berman, Holly Sundberg Malek, Michael Bitzer, Nisar Malek, Carsten Eickhoff

J Med Internet Res 2025 (Mar 05); 27:e64364

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Advancing Health Care With Digital Twins: Meta-Review of Applications and Implementation Challenges

Mickaël Ringeval, Faustin Armel Etindele Sosso, Martin Cousineau, Guy Paré

J Med Internet Res 2025 (Feb 19); 27:e69544

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Histopathological Comparison and Expression Analysis of COL1A1, COL3A1, and ELN in the Proximal and Distal Ventral Dartos of Patients With Hypospadias: Protocol for Prospective Case-Control Study

Putu Angga Risky Raharja, Ponco Birowo, Lisnawati Rachmadi, Heri Wibowo, Aria Kekalih, Gede Wirya Kusuma Duarsa, Tariq Abbas, Irfan Wahyudi

JMIR Res Protoc 2025 (Feb 18); 14:e70075

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