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Skip search results from other journals and go to results- 9805 Journal of Medical Internet Research
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In this tutorial, we use a case study based on MS to illustrate the deployment of our pipeline in conducting an observational clinical research study. The clinical question of interest is to compare the long-term treatment effectiveness between 2 groups of high-efficacy MS DMTs, namely, B-cell depletion therapies (eg, ocrelizumab) versus alpha4-integrin blockers (eg, natalizumab). For MS, a common treatment efficacy measure in RCTs is the reduction in acute inflammatory relapse events.
J Med Internet Res 2025;27:e71873
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We conducted an exploratory cross-sectional analysis using the Ao U Controlled Tier version 7 data release in the secure, cloud-based Ao U Researcher Workbench platform (date of first access for research purposes: September 1, 2023; date of last access: June 16, 2024). Registered researchers can access the data through the Ao U Research Hub [7]. This study was exempt from ethical approval for human subjects research as only deidentified data were analyzed.
JMIR Form Res 2025;9:e69138
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Therefore, this dataset is adequate to answer the research questions.
Missing data analysis was conducted, and variables with more than 30% missing values were excluded to enhance model robustness. Missing data were imputed using Multivariate Imputation by Chained Equations. See Multimedia Appendix 1 for details on the percentage of missing data for each variable before imputation.
JMIR Cardio 2025;9:e68066
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Foremost, eligible individuals received an introductory letter cosigned by their physician provider, such as a physician or nurse practitioner to introduce the research study, accompanied by a brochure, contact information, and a stamped postcard to decline participation. Individuals who did not return the postcard within 2‐4 weeks received a telephone call as described by the letter.
JMIR Cardio 2025;9:e66436
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Research indicates that a significant proportion of the adverse functional and health outcomes experienced by older adults during hospitalization may not be directly linked to their underlying health conditions or the reasons for hospitalization [1-3]. Instead, they may arise from certain hospital practices, such as restricted physical activity and immobilization, which may be harmful for older patients, especially for those who are frail [1].
JMIR Aging 2025;8:e64372
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Implementation of New Technologies in an Aged Care Social Day Program: Mixed Methods Evaluation
This research aimed to undertake a multifaceted evaluation of the implementation of technologies at the Social Day Program, including an exploration of the barriers and enablers to the use of technology within the Social Day Program.
JMIR Aging 2025;8:e60297
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In this work, we draw on our multivariable models in conjunction with recent research on the causal interpretation of predictive models [17] and on the appropriate selection of covariates [18]. Based on this approach, we assess the independent effect of proposed driving factors for the adolescent mental health crisis (increased screen time, less physical activity, and worsened peer relationships).
JMIR Public Health Surveill 2025;11:e60125
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A particularity of our cohort appears to be a very high interest in science and in completing a doctoral thesis, while globally, medical students rather underscore the necessity and importance of research in medical education, with many students reporting positive attitudes and interest in research efforts [18].
Data protection and IT security were the highest ranking in terms of relevance among our students. Students also reported a significant increase in competence after completing the curriculum.
JMIR Form Res 2025;9:e58940
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The questionnaire used in this study was developed de novo by the research team. The design process was informed by the research team’s multidisciplinary experience in medicine, education, and digital health, as well as the evolving discourse around AI in health care. To assist with rapid prototyping, the research team used Chat GPT (Open AI) to generate the first draft of the questionnaire. This initial draft provided a foundation for question phrasing and thematic organization.
JMIR Med Educ 2025;11:e58801
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Considering the variety of multimodal MCI interventions, both with and without technology, and the diverse methodologies and research focus of the existing literature, a scoping review is warranted to identify the current research gaps to inform future research and clinical practice.
JMIR Aging 2025;8:e70291
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