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Algorithmic Classification of Psychiatric Disorder–Related Spontaneous Communication Using Large Language Model Embeddings: Algorithm Development and Validation

Algorithmic Classification of Psychiatric Disorder–Related Spontaneous Communication Using Large Language Model Embeddings: Algorithm Development and Validation

Therefore, we hypothesize that, given the differences in patterns of speech by individuals across psychiatric disorders, spontaneous use of language will occupy diagnosis-specific subspaces in the LLM embedding space.

Ryan Allen Shewcraft, John Schwarz, Mariann Micsinai Balan

JMIR AI 2025;4:e67369

Using Large Language Models to Enhance Exercise Recommendations and Physical Activity in Clinical and Healthy Populations: Scoping Review

Using Large Language Models to Enhance Exercise Recommendations and Physical Activity in Clinical and Healthy Populations: Scoping Review

Transparent communication about data collection, robust validation mechanisms, and regulatory frameworks prioritizing inclusivity and fairness are crucial to maximize the potential of LLM-driven health interventions while ensuring scientifically grounded and emotionally supportive recommendations [29,31]. One critical yet underexplored aspect of LLM development in ERs and PA is the lack of transparency regarding training data and fine-tuning methodologies.

Xiangxun Lai, Jiacheng Chen, Yue Lai, Shengqi Huang, Yongdong Cai, Zhifeng Sun, Xueding Wang, Kaijiang Pan, Qi Gao, Caihua Huang

JMIR Med Inform 2025;13:e59309

A Comparison of Responses from Human Therapists and Large Language Model–Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study

A Comparison of Responses from Human Therapists and Large Language Model–Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study

Emerging evidence suggests that LLM-based chatbots as social companions can offer positive support and contribute to general psychological wellness [3,4]. There have been numerous studies, especially focused on the AI companion app Replika, that found positive mental health outcomes of using chatbots, such as increased confidence and improved relationships with friends [4,5].

Till Scholich, Maya Barr, Shannon Wiltsey Stirman, Shriti Raj

JMIR Ment Health 2025;12:e69709

Assessing ChatGPT’s Capability as a New Age Standardized Patient: Qualitative Study

Assessing ChatGPT’s Capability as a New Age Standardized Patient: Qualitative Study

Since its introduction in November 2022, sectors spanning from history to entertainment have rapidly adopted the LLM [10]. This advancement in AI has led to the development of virtual SP chatbots. A number of major educational material suppliers and specialized companies are offering chatbot SPs, based on LLMs capable of natural language interactions, for students to practice clinical skills.

Joseph Cross, Tarron Kayalackakom, Raymond E Robinson, Andrea Vaughans, Roopa Sebastian, Ricardo Hood, Courtney Lewis, Sumanth Devaraju, Prasanna Honnavar, Sheetal Naik, Jillwin Joseph, Nikhilesh Anand, Abdalla Mohammed, Asjah Johnson, Eliran Cohen, Teniola Adeniji, Aisling Nnenna Nnaji, Julia Elizabeth George

JMIR Med Educ 2025;11:e63353

From E-Patients to AI Patients: The Tidal Wave Empowering Patients, Redefining Clinical Relationships, and Transforming Care

From E-Patients to AI Patients: The Tidal Wave Empowering Patients, Redefining Clinical Relationships, and Transforming Care

Among LLM users, half reported personal learning as their goal, and 39% sought information about physical or mental health [3]. Patients burdened with life-changing or rare conditions commonly search for the resources that they need to solve problems. As consumer costs of care keep rising and health care is relentlessly hard to navigate, patients and caregivers are gaining skills and intelligence using LLMs across a breadth of topics.

Susan S Woods, Sarah M Greene, Laura Adams, Grace Cordovano, Matthew F Hudson

J Particip Med 2025;17:e75794

Benchmarking the Confidence of Large Language Models in Answering Clinical Questions: Cross-Sectional Evaluation Study

Benchmarking the Confidence of Large Language Models in Answering Clinical Questions: Cross-Sectional Evaluation Study

This raises questions about the underlying mechanisms that prompt an LLM to label certain statements as “more factual.” For example, one possible explanation could be that data-rich or frequently discussed topics in training sets may be perceived as more certain [18], even if this does not translate into clinical accuracy. Additionally, retrieval-augmented generation (RAG) has been proposed to ground LLM outputs in external data, which potentially mitigates hallucinations [19].

Mahmud Omar, Reem Agbareia, Benjamin S Glicksberg, Girish N Nadkarni, Eyal Klang

JMIR Med Inform 2025;13:e66917

Evaluating Generative AI in Mental Health: Systematic Review of Capabilities and Limitations

Evaluating Generative AI in Mental Health: Systematic Review of Capabilities and Limitations

LLMs such as Chat GPT, Claude, and Bard hold great promise in mitigating this stark situation to reduce clinicians’ burden and increase clinician efficiency through LLM-assisted clinical notes writing, formulating differential diagnoses, drafting personalized treatment plans, drawing insights from patient chart data, providing on-demand coaching and companionship, and, ultimately, providing therapy [10,11].

Liying Wang, Tanmay Bhanushali, Zhuoran Huang, Jingyi Yang, Sukriti Badami, Lisa Hightow-Weidman

JMIR Ment Health 2025;12:e70014

Global Health care Professionals’ Perceptions of Large Language Model Use In Practice: Cross-Sectional Survey Study

Global Health care Professionals’ Perceptions of Large Language Model Use In Practice: Cross-Sectional Survey Study

Large language model (LLM) refers to advanced artificial intelligence (AI) models designed for natural language processing tasks. LLMs are trained on vast amounts of text data and use deep learning techniques to understand and generate human-like language. They helped transform various fields, including medicine [1]. Some examples of most popular LLMs are Lla MA by Meta, Orca and Phi-1 by Microsoft, BLOOM, Pa LM2 by Google, and GPT by Open AI.

Ecem Ozkan, Aysun Tekin, Mahmut Can Ozkan, Daniel Cabrera, Alexander Niven, Yue Dong

JMIR Med Educ 2025;11:e58801