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The most frequently used CPSs in children are the Alvarado score [2], the Pediatric Appendicitis Score (PAS) [3], and the pediatric appendicitis risk calculator (p ARC) [4], with each based on different sets of collected variables.
The Alvarado score is one of the most widely studied CPSs for the diagnosis of acute appendicitis in adult populations based on 8 variables with a total score of 10 [2], and it has since been studied in pediatric populations with varying results [33-44].
JMIR Res Protoc 2025;14:e67941
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Solifenacin and mirabegron are widely used off-label in the pediatric population, and only a few studies have dealt with the efficacy and tolerability of these agents [10-14]. Only 1 study has evaluated combination therapy [14].
Since the pharmacological approach is widely used off-label in pediatric departments, an evidence-based treatment approach of pharmacological therapy is highly needed.
JMIR Res Protoc 2025;14:e63588
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Impacting low-SES caregiver knowledge, language behaviors, and infant vocabulary skills through a web-based pediatricpediatric
JMIR Pediatr Parent 2025;8:e66175
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Reference 30: Health-related quality of life in pediatric patients with syndromic autism and their caregiverspediatricCaregiving and Parenting for Chronic Pediatric Diseases
JMIR Pediatr Parent 2025;8:e67872
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However, in the past 3 years, an average of only 216 pediatric patients were diagnosed with cancer annually [5]. This suggests that the remaining 75%‐80% of patients remain undiagnosed and likely do not survive (Figure 1). One example is pediatric leukemia, the most common type of pediatric cancer in this region. Although this malignancy should represent 300‐480 cases (ie, 30%‐40% of all pediatric cancer diagnosis), only 40 cases per year have been seen over the last several years [5].
JMIR Form Res 2025;9:e59776
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Pediatric hematopoietic stem cell transplants (HCTs) are an intensive life-saving treatment for several malignant and nonmalignant disorders [1]. However, HCT often requires a long hospital stay that is stressful for the children and their caregivers [2]. Symptom and medication management are important components of the HCT experience, and it is critical for caregivers to adhere to recommendations and communicate with the care team [3].
JMIR Cancer 2025;11:e66847
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We modeled our efforts on the process by Palermo et al [36] and Mc Grath et al [39] of establishing a COS for pediatric chronic pain clinical trials and the original Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (Ped IMMPACT) consensus processes. We used the OMERACT framework [37,38] to choose outcome domains using clinician and researcher input followed by an expert consensus meeting that included people with lived experience.
J Med Internet Res 2025;27:e58947
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