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Patients’ Expectations for App-Based Therapy in Knee Osteoarthritis: User-Centered Design Approach

Patients’ Expectations for App-Based Therapy in Knee Osteoarthritis: User-Centered Design Approach

Knee osteoarthritis (KOA) is a prevalent degenerative joint disease affecting 16% of individuals aged 15+ years and 22.9% of those aged 40+ years [1]. As a leading musculoskeletal disorder [2], it poses a growing economic and health burden [3-5], necessitating effective management strategies to mitigate symptoms and improve patient outcomes.

Pika Krištof Mirt, Karmen Erjavec, Sabina Krsnik, Petra Kotnik, Hussein Mohsen

JMIR Rehabil Assist Technol 2025;12:e64607

Effects of a Computer Vision–Based Exercise Application for People With Knee Osteoarthritis: Randomized Controlled Trial

Effects of a Computer Vision–Based Exercise Application for People With Knee Osteoarthritis: Randomized Controlled Trial

Knee osteoarthritis (KOA) is a common and chronic joint disorder that is growing in prevalence as the world’s population ages [1,2]. Exercise has been acknowledged as a nonpharmacological intervention modality for the treatment and prevention of musculoskeletal disorders, including osteoarthritis, osteoporosis, back pain, and rheumatoid arthritis [3].

Dian Zhu, Jianan Zhao, Tong Wu, Beiyao Zhu, Mingxuan Wang, Ting Han

JMIR Mhealth Uhealth 2025;13:e63022

Comparing Artificial Intelligence–Generated and Clinician-Created Personalized Self-Management Guidance for Patients With Knee Osteoarthritis: Blinded Observational Study

Comparing Artificial Intelligence–Generated and Clinician-Created Personalized Self-Management Guidance for Patients With Knee Osteoarthritis: Blinded Observational Study

Knee osteoarthritis (OA) is a prevalent, chronic, degenerative joint disorder that imposes a substantial burden on patients’ quality of life and overall well-being [1]. Epidemiological studies have revealed that knee osteoarthritis affects hundreds of millions of individuals worldwide, with its prevalence increasing with age [2].

Kai Du, Ao Li, Qi-Heng Zuo, Chen-Yu Zhang, Ren Guo, Ping Chen, Wei-Shuai Du, Shu-Ming Li

J Med Internet Res 2025;27:e67830

Can Artificial Intelligence Diagnose Knee Osteoarthritis?

Can Artificial Intelligence Diagnose Knee Osteoarthritis?

We queried Chat GPT (using the GPT-4o version) and assessed its performance in classifying 500 X-ray images of normal knees and 500 images of knees with osteoarthritis from a publicly available Kaggle database [7]. Images were verified based on consensus among radiologists. A single standardized prompt was used: “This is an x-ray image found on examination, the multiple-choice question is as follows. Based on the x-ray image, does the patient have A) no osteoarthritis, B) osteoarthritis.”

Mihir Tandon, Nitin Chetla, Adarsh Mallepally, Botan Zebari, Sai Samayamanthula, Jonathan Silva, Swapna Vaja, John Chen, Matthew Cullen, Kunal Sukhija

JMIR Biomed Eng 2025;10:e67481

Effects of an e-Learning Program (Physiotherapy Exercise and Physical Activity for Knee Osteoarthritis [PEAK]) on Chinese Physical Therapists’ Confidence and Knowledge: Randomized Controlled Trial

Effects of an e-Learning Program (Physiotherapy Exercise and Physical Activity for Knee Osteoarthritis [PEAK]) on Chinese Physical Therapists’ Confidence and Knowledge: Randomized Controlled Trial

Osteoarthritis (OA) is a multifactorial joint disease that is highly prevalent worldwide, affecting 133 million people in China as of 2019 [1]. The burden of OA in China is projected to continue rising until 2044 due to the aging population, rising obesity rates, and the country’s large population size [2,3].

Zi-Ru Wang, Yunqi Wang, Shuning Duan, Xier Chen, Guoxin Ni

J Med Internet Res 2025;27:e71057

Effectiveness of Stromal Vascular Fraction (SVF) and Platelet-Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Protocol for a Phase 3, Prospective, Randomized, Controlled, Multicenter Study (SPOST Study)

Effectiveness of Stromal Vascular Fraction (SVF) and Platelet-Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Protocol for a Phase 3, Prospective, Randomized, Controlled, Multicenter Study (SPOST Study)

Osteoarthritis, the most common joint disease [1], has a high social and individual impact, and the development of therapeutic options is a public health priority. Its multifactorial etiology is still a source of active research [2,3]. The most common conservative treatments for osteoarthritis include painkillers, active physical therapies, orthotics, corticosteroid infiltrations, hyaluronic acid, and platelet-rich plasma (PRP) [1,4].

Adrien Schwitzguebel, David Andres Ramirez Cadavid, Tamara Da Silva, Pierre Decavel, Charles Benaim

JMIR Res Protoc 2025;14:e62659

Convergent and Known-Groups Validity and Sensitivity to Change of the Virtual Performance Measure in Patients With Hip and Knee Osteoarthritis: Longitudinal Study

Convergent and Known-Groups Validity and Sensitivity to Change of the Virtual Performance Measure in Patients With Hip and Knee Osteoarthritis: Longitudinal Study

Osteoarthritis of the hip and knee joint is a disabling condition in older adults with significant physical, social, and economic burdens. Traditionally, two types of outcome measurement have been used in the assessment of patients with lower-extremity osteoarthritis. Patient-reported outcome measures document perceived physical difficulty within a specific timeframe [1].

Helen Razmjou, Suzanne Denis, Susan Robarts, Amy Wainwright, Patricia Dickson, John Murnaghan

JMIR Form Res 2025;9:e69001

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Osteoarthritis is a degenerative joint disease [1] affecting synovial joints and is a leading cause of pain and disability among adults [2]. Knee osteoarthritis is the most common type, with data indicating that 45% of people may develop symptomatic knee osteoarthritis in their lifetime [3]. Accordingly, knee osteoarthritis is the most prevalent type of osteoarthritis in Africans [4], accounting for 65%-78% of cases in hospitals in Nigeria [5].

Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

J Med Internet Res 2025;27:e58393

Personalized Predictions for Changes in Knee Pain Among Patients With Osteoarthritis Participating in Supervised Exercise and Education: Prognostic Model Study

Personalized Predictions for Changes in Knee Pain Among Patients With Osteoarthritis Participating in Supervised Exercise and Education: Prognostic Model Study

Osteoarthritis (OA) is a chronic disease characterized by persistent joint pain and limited mobility, especially for those who experience from OA of the knee [1]. In the United States alone, the overall economic burden of OA is estimated at almost US $140 billion annually, highlighting the substantial societal and personal costs associated with the condition [2].

Mahdie Rafiei, Supratim Das, Mohammad Bakhtiari, Ewa Maria Roos, Søren T Skou, Dorte T Grønne, Jan Baumbach, Linda Baumbach

JMIR Rehabil Assist Technol 2025;12:e60162

Behavioral Therapy–Based Digital Interventions for Treating Osteoarthritis: Systematic Review and Meta-Analysis

Behavioral Therapy–Based Digital Interventions for Treating Osteoarthritis: Systematic Review and Meta-Analysis

Osteoarthritis (OA) is a prevalent joint disease affecting 29.7% of the population older than 40 years [1]. OA is characterized by pain, functional impairments, muscle weakness, joint stiffness, and reduced health-related quality of life (HRQo L) [2,3]. This causes heightened reliance on heath care resources and exacerbates socioeconomic burden [4,5].

Beiyao Zhu, Dian Zhu, Xiao'ao Xue, Hongyi Yang, Shurong Zhang

J Med Internet Res 2025;27:e56227