e.g. mhealth
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Previous reviews on interoperability have not focused on specific industries such as health care, nor have they consistently provided structured classifications. One review addressed user model interoperability but lacked a systematic approach [17]. Another study examined evaluation models of interoperability, categorizing 12 models across 4 granularity levels [10]. While this study mentioned interoperability attributes, these were not developed through a systematic procedure [10].
J Med Internet Res 2025;27:e69465
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To facilitate this exchange, HIE requires a data exchange or data interoperability framework that provides a standardized format for transferring health data [2]. One of the organizations that provides such interoperability frameworks is Health Level Seven (HL7) [3]. HL7 is a nonprofit organization that develops interoperability frameworks, such as HL7 FHIR (Fast Healthcare Interoperability Resources). It is a newer standard that provides a modern and flexible approach to exchanging health information.
JMIR Form Res 2025;9:e51270
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In Germany, the Medical Informatics Initiative (MII) has established a large-scale data sharing network [19] based on electronic health record data from university hospitals, using the Health Level 7 (HL7) Fast Health care Interoperability Resources (FHIR) standard for data integration [20]. Hospitals harmonize heterogeneous clinical data in local data integration centers (DICs) nationwide, and a central portal has been established to access this data [21].
J Med Internet Res 2025;27:e65681
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It advocates for using existing International Organization for Standardization (ISO) standards to ensure consistency and interoperability. TEHDAS focuses on data interoperability, identifying standards for data discovery and common data models.
J Med Internet Res 2025;27:e66273
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interoperabilityStandards and Interoperability
JMIR Form Res 2025;9:e63902
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We explore the strengths and limitations of digital PADs and emphasize that for the innovation to work, it is essential that the PADs are interoperable, ideally integrated into each country’s health care data infrastructure via Fast Healthcare Interoperability Resources.
J Med Internet Res 2025;27:e68549
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Data Interoperability in COVID-19 Vaccine Trials: Methodological Approach in the VACCELERATE Project
Interoperability is defined as the ability of different information systems, devices, or applications to connect in a coordinated manner within and across organizational boundaries, enabling stakeholders to access, exchange, and cooperatively use data with the goal of optimizing the health of individuals and populations [1].
Interoperability standards provide a common language and set of expectations that enable interoperability between systems and devices.
JMIR Med Inform 2025;13:e65590
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Therefore, it should be optimized to enhance data quality and data interoperability.
Ideally, a standard operating procedure is established initially for designing e CRFs.
Interact J Med Res 2025;14:e51598
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To deliver sustainable digital health solutions for country impact, digital system development needs to be based on principles of transparency, accessibility, scalability, and interoperability [6]; be adherent to clinical guidelines [7] and data use and sharing standards; and be guided by national digital strategies.
JMIR Med Inform 2025;13:e58858
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We used qualitative content analysis to identify key themes using the existing United States Core Data for Interoperability (USCDI) ONC New Data Element and Class Submission System, focusing on new data element submission requirements and emergent themes from gaps in the literature.
J Med Internet Res 2025;27:e62670
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