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Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

These symptoms affect cognitive functions—such as attention and memory—to varying degrees. Cognitive impairment is the most common symptom among patients with CFS and has the greatest impact on daily functioning and learning abilities [7]. In 2021, the UK’s National Institute for Health and Clinical Excellence (NICE) included cognitive impairment (brain fog) as 1 of the 4 core symptoms of CFS.

Bin Wang, Xiaodong Zhang, Ping Lu, Pingping Sun, Tianxiang He

JMIR Res Protoc 2025;14:e65958

Association of Virtual Nurses’ Workflow and Cognitive Fatigue During Inpatient Encounters: Cross-Sectional Study

Association of Virtual Nurses’ Workflow and Cognitive Fatigue During Inpatient Encounters: Cross-Sectional Study

Pupillometry data, which measures the change in pupil size, measures cognitive fatigue [17]. This study examined the association between using virtual nursing and virtual nurse fatigue using eye-tracking technology. Eye-tracking technology provides real-time insights into cognitive workload and cognitive fatigue by recording eye movements during different states and activities.

Saif Khairat, Jennifer Morelli, Wan-Ting Liao, Julia Aucoin, Barbara S Edson, Cheryl B Jones

JMIR Hum Factors 2025;12:e67111

Transdiagnostic Compulsivity Traits in Problematic Use of the Internet Among UK Residents: Cross-Sectional Network Analysis Study

Transdiagnostic Compulsivity Traits in Problematic Use of the Internet Among UK Residents: Cross-Sectional Network Analysis Study

We identified several strong mechanistic pathways, notably the edge between cognitive rigidity and coping and the edge between reward drive and functional impairment (ie, negative financial consequences). Finally, reward drive and cognitive rigidity were identified as the bridge nodes. When elucidating interrelationships between compulsivity dimensions and PUI symptoms, we found that cognitive rigidity was associated with coping-motivated internet use.

Chang Liu, Samuel Chamberlain, Konstantinos Ioannidis, Jeggan Tiego, Jon Grant, Murat Yücel, Peter Hellyer, Christine Lochner, Adam Hampshire, Lucy Albertella

J Med Internet Res 2025;27:e66191

Effectiveness of General Practitioner Referral Versus Self-Referral Pathways to Guided Internet-Delivered Cognitive Behavioral Therapy for Depression, Panic Disorder, and Social Anxiety Disorder: Naturalistic Study

Effectiveness of General Practitioner Referral Versus Self-Referral Pathways to Guided Internet-Delivered Cognitive Behavioral Therapy for Depression, Panic Disorder, and Social Anxiety Disorder: Naturalistic Study

Cognitive behavioral therapy (CBT) is the psychological treatment with the strongest empirical support [11] and it is the recommended first-line treatment for these disorders [12,13]. Internet-delivered cognitive behavioral therapy (ICBT) delivers evidence-based CBT specifically targeting, but not limited to, depression and anxiety disorders [14].

Jill Bjarke, Rolf Gjestad, Tine Nordgreen

JMIR Ment Health 2025;12:e68165

Digital Assessment of Cognitive Health in Outpatient Primary Care: Usability Study

Digital Assessment of Cognitive Health in Outpatient Primary Care: Usability Study

Dementia is a neurodegenerative disorder characterized by progressive deficits in one or more cognitive domains severe enough to interfere with an individual’s functional status [1]. Mild cognitive impairment (MCI) is a precursor of dementia, characterized by more subtle cognitive deficits that do not interfere with functional status [1]. Although definitional variability and reporting bias complicate the estimation of prevalence [2], MCI likely afflicts 12% to 18% of people aged 60 years and older [3,4].

Adam J Doerr, Taylor A Orwig, Matthew McNulty, Stephanie Denise M Sison, David R Paquette, Robert Leung, Huitong Ding, Stephen B Erban, Bruce R Weinstein, Yurima Guilarte-Walker, Adrian H Zai, Allan J Walkey, Apurv Soni, David D McManus, Honghuang Lin

JMIR Form Res 2025;9:e66695

Machine Learning Analysis of Engagement Behaviors in Older Adults With Dementia Playing Mobile Games: Exploratory Study

Machine Learning Analysis of Engagement Behaviors in Older Adults With Dementia Playing Mobile Games: Exploratory Study

Cognitive impairments, such as dementia, are typically assessed and monitored by health care professionals during routine clinical examinations or when an older adult or their family members identify symptoms of cognitive decline and seek assistance [3]. Limitations of current screening have spurred research into the development of alternative, more naturalistic methods to monitor for cognitive decline.

Melika Torabgar, Mathieu Figeys, Shaniff Esmail, Eleni Stroulia, Adriana M Ríos Rincón

JMIR Serious Games 2025;13:e54797

Real-World Insights Into Dementia Diagnosis Trajectory and Clinical Practice Patterns Unveiled by Natural Language Processing: Development and Usability Study

Real-World Insights Into Dementia Diagnosis Trajectory and Clinical Practice Patterns Unveiled by Natural Language Processing: Development and Usability Study

While previous research has made significant strides in the earlier detection of cognitive decline using EHR, most studies have focused on extracting symptoms or cognitive measurement scores rather than other clinical features that affect disease progression, such as the relationship of the primary caregivers with patients.

Hunki Paek, Richard H Fortinsky, Kyeryoung Lee, Liang-Chin Huang, Yazeed S Maghaydah, George A Kuchel, Xiaoyan Wang

JMIR Aging 2025;8:e65221

Tablet- and Group-Based Multicomponent Cognitive Stimulation for Older Adults With Mild Cognitive Impairment: Single-Group Pilot Study and Protocol for Randomized Controlled Trial

Tablet- and Group-Based Multicomponent Cognitive Stimulation for Older Adults With Mild Cognitive Impairment: Single-Group Pilot Study and Protocol for Randomized Controlled Trial

In addition, subjective cognitive decline has been linked to anxiety symptoms, independently increasing the risk of MCI or dementia [7]. Depression is also associated with early cognitive impairment, but patients with depression typically do not exhibit the memory deficits observed in MCI or dementia [8,9]. Group-based cognitive stimulation therapy (CST) has been shown to improve both cognitive functions and quality of life in older adults with dementia or MCI [10,11].

Khanitin Jornkokgoud, Pattrawadee Makmee, Peera Wongupparaj, Alessandro Grecucci

JMIR Res Protoc 2025;14:e64465

How Patients With Cancer Use the Internet to Search for Health Information: Scenario-Based Think-Aloud Study

How Patients With Cancer Use the Internet to Search for Health Information: Scenario-Based Think-Aloud Study

For example, patients may do so to address their cognitive (ie, the need for understanding) and affective (ie, the need to be understood) needs [13]. Cognitive needs (eg, engaging with the internet to enhance preparedness and comprehension of the information provided during a consultation or to validate or challenge the information offered by the provider) will lead to diverse forms of WHIS compared to affective needs (eg, using the internet for peer interaction).

Fiorella Huijgens, Pascale Kwakman, Marij Hillen, Julia van Weert, Monique Jaspers, Ellen Smets, Annemiek Linn

JMIR Infodemiology 2025;5:e59625