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Skip search results from other journals and go to results- 3 JMIR Research Protocols
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Therefore, those symptoms, or their anticipation, can impede successful transmucosal buprenorphine discontinuation [19,26-28]. Patients report challenges with tapering buprenorphine, particularly with the transition from 2 mg transmucosal buprenorphine to no treatment, using strategies such as cutting strips or dissolving tablets in water to achieve smaller buprenorphine doses to facilitate tapering and minimize withdrawal symptoms [29].
J Med Internet Res 2025;27:e71245
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One Medicaid data study following over 90,000 patients showed remarkable positive outcomes from telemedicine initiation of buprenorphine treatment, including better odds of 90-day treatment retention than if initiation occurred in person [12]. In a scoping review from 2008 to March 18, 2021, reviewers found that telehealth technology in SUD treatment increased access and adherence to buprenorphine and generally showed higher patient satisfaction and comparability to in-person retention rates [11].
JMIR Hum Factors 2025;12:e65419
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Telemedicine Prescribing by US Mental Health Care Providers: National Cross-Sectional Survey
In part, this enabled crucial access to buprenorphine for opioid use disorder treatment [4,5]. Now, consumers and stakeholders are calling for new policy that enables continued access to mental health care and substance use treatment, including medication-based treatment, via telemedicine [6]. The challenge is to develop evidence-based policy that supports safety while enabling critical health care access.
JMIR Form Res 2025;9:e63251
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Furthermore, patients taking medication for OUD (MOUD), including either buprenorphine or methadone, are of specific interest because of their risk for unmanaged pain-triggering relapse. Indeed, patients taking MOUD often have difficulty accessing nonpharmacological treatments and many report unmanaged pain as the primary reason for opioid relapse [24].
JMIR Res Protoc 2024;13:e53784
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Buprenorphine and naloxone (BUP and NAL) can reduce opioid overdose deaths by at least 70%, decrease opioid misuse, and improve quality of life [3-6]. Because of its demonstrated efficacy, the National Institute on Drug Abuse, the Substance Abuse and Mental Health Services Administration, the American Society of Addiction Medicine, and the American Academy of Addiction Psychiatry endorse the use of medications for opioid use disorder in the treatment of opioid use disorder (eg, BUP and NAL and methadone).
JMIR Form Res 2023;7:e40437
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In combating the opioid crisis, buprenorphine is the drug of choice when adhering to an evidence-based clinical standard of care. However, the Drug Addiction Treatment Act of 2000 mandates those clinicians receive a waiver known as the Drug Enforcement Administration (DEA)-X waiver in order to prescribe buprenorphine [1].
JMIR Hum Factors 2023;10:e40244
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The re SET-O PDT was authorized by the FDA in 2018 for patients with OUD being treated with buprenorphine.
JMIR Res Protoc 2023;12:e43122
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Opioid Use Disorder Education for Students and the Future of Opioid Overdose Treatment
Buprenorphine is a US Food and Drug Administration (FDA)–approved medication used as a medication-assisted treatment (MAT) by acting as a partial opioid agonist. It is used to treat OUD along with a comprehensive treatment program that includes various behavioral therapies and counseling. Buprenorphine is a key step toward increasing treatment access for patients with OUD [5].
JMIR Med Educ 2022;8(3):e37081
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Buprenorphine (brand names Suboxone, Subutex, etc) and methadone are first-line treatments for opioid withdrawal and maintenance therapy [23]. Unlike methadone, buprenorphine is a partial receptor agonist with a ceiling effect, meaning that additional doses beyond a threshold do not produce an increased effect. This feature renders buprenorphine safer than other full agonist opioids, an important factor since methadone overdose is a serious risk with methadone treatment [24-26].
JMIR Public Health Surveill 2022;8(4):e32133
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Recently, a brief negotiation interview (BNI), the treatment of withdrawal with buprenorphine-naloxone as appropriate, and referral to treatment have been shown to be an effective strategy for OUD treatment.
JMIR Res Protoc 2021;10(4):e18734
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