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Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

This would occur in the intervention arm only, but there will not be any syphilis testing done by systems navigators (they only collect urine for N. gonorrhea and C. trachomatis). All participants will complete study staff-administered surveys using validated scales whenever possible, enabling exploration of predictors of Pr EP persistence and informing targeted objectives and strategies to enhance systems navigation and counseling interventions.

Sarah E Rutstein, Laura Limarzi-Klyn, Jane S Chen, Yaw O Agyei, Shahnaz Ahmed, Ian Bell, Myron Cohen, Jessica M Fogel, Vivian Go, Dan Haines, Erica L Hamilton, Irving F Hoffman, Mina C Hosseinipour, Mark A Marzinke, William C Miller, Mathews Mukatipa, Julie Pulerwitz, Hans M L Spiegel, Ting Ye, Mitch Matoga

JMIR Res Protoc 2025;14:e72981

AI-Powered Drug Classification and Indication Mapping for Pharmacoepidemiologic Studies: Prompt Development and Validation

AI-Powered Drug Classification and Indication Mapping for Pharmacoepidemiologic Studies: Prompt Development and Validation

Using the example of lisinopril and hydrochlorothiazide, the first level ATC code is “C” for cardiovascular, the organ or system acted upon, the second-level ATC code is “C09” for agents acting on the renin–angiotensin system, and the fifth-level ATC code is “C09 BA03”: lisinopril and diuretics [12,13]. While there is the basic principle of 1 ATC code for each drug [12], here the fifth-level ATC code is still ambiguous due to the presence of an unspecified diuretic.

Benjamin Ogorek, Thomas Rhoads, Eric Finkelman, Isaac R Rodriguez-Chavez

JMIR AI 2025;4:e65481

Sexual Health Determinants During the Life Course and Migration of Haitian-Origin People in French Guiana: Protocol for the Parcours d’Haïti Biographical and Transdisciplinary Study

Sexual Health Determinants During the Life Course and Migration of Haitian-Origin People in French Guiana: Protocol for the Parcours d’Haïti Biographical and Transdisciplinary Study

For the group of people living with HIV, the inclusion criteria were as follows: living with HIV and having a diagnosis dating back >3 months (whatever their status with regard to hepatitis B and C), as well as being followed up on by one of the study’s partner physicians at the hospitals in Cayenne, Kourou, or Saint-Laurent-du-Maroni; in outpatient care; or by a partner association.

Leslie Alcouffe, Marc-Alexandre Tareau, Gabriel Brun Rambaud, Aude Lucarelli, Mathilde Boutrou, Camille Thorey, Greta Cantalupi, Karl Kpossou, Florence Huber, Sébastien Rabier, Dévi Rita Rochemont, Théo Blaise, Estelle Thomas, Guerline Jean, Ruth Pierre Louis, Annette Zephirin, Célia Basurko, Félix Djossou, Hawa Cissé, William Faurous, Quentin Drouaud, Mayka Mergeay-Fabre, Antoine Adenis, Mathieu Nacher, Nicolas Vignier

JMIR Res Protoc 2025;14:e63586

Digital Mental Health Interventions for the Prevention and Treatment of Social Anxiety Disorder in Children, Adolescents, and Young Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Digital Mental Health Interventions for the Prevention and Treatment of Social Anxiety Disorder in Children, Adolescents, and Young Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials

interpretation. k We obtained unpublished, SAD-specific outcome data, which were not included in the original outcome paper, directly from the authors. l MASC-SA: Multidimensional Anxiety Scale for Children, social anxiety subscale [115]. m LSASCA-SR: Liebowitz Social Anxiety Scale for Children and Adolescents, self-report version [116]. n OSCA: Online Social Anxiety Cognitive Therapy for Adolescents. o SIAS: Social Interaction Anxiety Scale [117]. p SCASy: Spence Children's Anxiety Scale, youth report [118]. q LSAS-C:

Noemi Walder, Alessja Frey, Thomas Berger, Stefanie Julia Schmidt

J Med Internet Res 2025;27:e67067