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Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

Nonliterate participants will document their informed consent by marking their ICF(s) (eg, with an X, thumbprint, or other mark) in the presence of a literate third-party witness. Participants will be provided with a copy of their ICF if they are willing to receive it. All minors (under the age of 18) will be required to provide assent along with parental consent. According to Malawi guidelines, individuals aged 15 years and above may initiate Pr EP if they meet other eligibility criteria.

Sarah E Rutstein, Laura Limarzi-Klyn, Jane S Chen, Yaw O Agyei, Shahnaz Ahmed, Ian Bell, Myron Cohen, Jessica M Fogel, Vivian Go, Dan Haines, Erica L Hamilton, Irving F Hoffman, Mina C Hosseinipour, Mark A Marzinke, William C Miller, Mathews Mukatipa, Julie Pulerwitz, Hans M L Spiegel, Ting Ye, Mitch Matoga

JMIR Res Protoc 2025;14:e72981

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Effect of Live Environmental Music Therapy and Prerecorded Music on State Anxiety, Stress, Pain, and Well-Being Levels of Patients and Caregivers in the Emergency Department Waiting Room: Protocol for a Multicenter Randomized Clinical Trial

Angélica Hernández, Ana María Díaz, Ornella Fiorillo Moreno, Raúl Suárez, Moshé Amarillo, Ana María Moreno, Bryan Alonso Ríos Suarez, Lina Marcela Gómez González, Guiselle Alexandra Cristancho Olaya, Mark Ettenberger

JMIR Res Protoc 2025;14:e69131

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College Community–Based Physical Activity Support at a Public University During the COVID-19 Pandemic: Retrospective Longitudinal Analysis of Intra- Versus Interpersonal Components for Uptake and Outcome Association

Garrett I Ash, Selene S Mak, Adrian D Haughton, Madilyn Augustine, Phillip O Bodurtha, Robert S Axtell, Beatrice Borsari, Jason J Liu, Shaoke Lou, Xin Xin, Lisa M Fucito, Sangchoon Jeon, Matthew Stults-Kolehmainen, Mark B Gerstein

JMIR Mhealth Uhealth 2025;13:e51707

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Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Respondents are asked to place a mark on the line representing their current feeling of intoxication, and its position is later measured using a ruler to extract a value. The experiment follows a repeated-measures, placebo-controlled (single-blind) crossover within-participant design (see Figure 3). The order of treatment was counterbalanced, such that half of the participants (n=15) received alcohol in their first session and a placebo in their second.

John Frederick Dyer, Florentine Marie Barbey, Ayan Ghoshal, Ann Marie Hake, Bryan J Hansen, Md Nurul Islam, Judith Jaeger, Rouba Kozak, Hugh Marston, Mark Moss, Viet Nguyen, Rebecca Louise Quinn, Leslie A Shinobu, Elizabeth Tunbridge, Brian Murphy, Niamh Kennedy