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Identifying New Risk Associations Between Chronic Physical Illness and Mental Health Disorders in China: Machine Learning Approach to a Retrospective Population Analysis

Identifying New Risk Associations Between Chronic Physical Illness and Mental Health Disorders in China: Machine Learning Approach to a Retrospective Population Analysis

In this study, the high comorbidity between “gastrointestinal diseases and neurotic stress disorders” (RR=1.821) aligns with the TCM theory of “liver qi stagnation and spleen deficiency,” where prolonged anxiety (liver qi stagnation) leads to digestive dysfunction (spleen deficiency). Furthermore, TCM’s holistic approach supports the bidirectional interaction between chronic physical and emotional conditions.

Lizhong Liang, Tianci Liu, William Ollier, Yonghong Peng, Yao Lu, Chao Che

JMIR AI 2025;4:e72599