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The exclusion of the study by Wang et al [29], which reported the lowest frailty prevalence (4.9%, 95% CI 3.7%‐6.4%), preserved excessive residual heterogeneity (I²=96%, P
Subsequent domain-specific analyses demonstrated differential heterogeneity profiles.
JMIR Cancer 2025;11:e69936
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The model was developed using Py Cox (version 0.2.3; Joseph Ramsey et al) on the Anaconda platform (version 3; Peter Wang et al), the Py Torch framework (version 1.12.1; Soumith Chintala et al), and the programming language Python (version 3.9; Guido van Rossum) as described by Kvamme and Borgan [28]. The traditional CPH model (Text S5 in Multimedia Appendix 1) is constrained by its inherent linear assumptions, which can limit its learnability from complex, multidimensional patient data.
J Med Internet Res 2025;27:e70118
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Current TCM formula textbooks and national standards still follow the efficacy-oriented classification system established in Wang Ang’s Qing Dynasty work Yi Fang Ji Jie (Compilation of Medical Formulas, 医方集解) [8]. Prior to the introduction of this system, many formulas lacked clear categorization, making manual classification both labor-intensive and susceptible to inconsistencies.
JMIR Med Inform 2025;13:e69286
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