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In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protocol for an Observational and Exploratory Study

In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protocol for an Observational and Exploratory Study

HRV demonstrates exceptional diversity, with 3 recognized species: HRV-A, HRV-B, and HRV-C. Each species includes numerous distinct serotypes, which can be differentiated through serological methods. At present, there are approximately 83 HRV-A, 32 HRV-B, and 55 HRV-C serotypes in circulation. Furthermore, high-resolution sequencing has identified multiple HRV serotypes within each serotype.

Sara Alonso Fernandez, Raquel Reyes-Manzanas, Susana Camara, Juan Mozas-Gutierrez, Myriam Calle-Rubio, Juan Rodriguez-Hermosa, Andres Bodas-Pinedo, Santiago Rueda Esteban, Esther M Lafuente, Jesús Reiné, Pedro A Reche

JMIR Res Protoc 2025;14:e73383