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Comparison of 5-Day Multidaily Neuronavigated Theta-Burst Sessions With 6-Week Standard Repetitive Transcranial Magnetic Stimulation (the Dutch Depression Outcome Trial): Protocol for a Randomized Controlled Trial

Comparison of 5-Day Multidaily Neuronavigated Theta-Burst Sessions With 6-Week Standard Repetitive Transcranial Magnetic Stimulation (the Dutch Depression Outcome Trial): Protocol for a Randomized Controlled Trial

Scans will be performed on a 3-T whole-body scanner with standardized and optimized sequences. Sequences included in the pre- and posttreatment scans are described in Textbox 1. Preprocessing of the functional and structural images is performed using the Freesurfer software suite, f MRIprep, an MRI quality control tool, and the FMRIB software library suite. Functional images are denoised and smoothed for stimulation target identification.

Annemiek Dols, Tom Biemans, Coen Coomans, Philip van Eijndhoven, Iris Dalhuisen, Ysbrand D van der Werf, Chris Vriend, Elvira S Amaral Gomes, Alexander T Sack, Teresa Schuhmann, Mashood Chaudhry, Martijn Arns, Bethany Hipple Walters, Ben Wijnen, Andrew Zalesky, Robin Cash, Daniel M Blumberger, Karel WF Scheepstra, Adriaan W Hoogendoorn, Odile A van den Heuvel, Eric van Exel, The D-DOTT Consortium

JMIR Res Protoc 2025;14:e70121

Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study

Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study

The primary outcome was quantification of IL-17 secretion from T cell receptor–activated CD4+ T cells isolated from samples collected on day 1 and day 4. The delta (change) in IL-17 secretion was compared using a 2-tailed paired t test. IL-17 secretion in response to TRE was compared between the 2 cohorts using a 2-tailed, 2-sample t test in each study group. The collected samples will also allow hypothesis generation to understand the molecular mechanisms underlying changes in IL-17 secretion.

Sinibaldo Romero Arocha, Kim Han, Rebecca D Huffstutler, Geethika P Thota, Natalie A Macheret, Amber B Courville, Robert J Brychta, Kong Y Chen, Stephanie T Chung, Laura C Coates, Alexander J Clarke, Michael N Sack

JMIR Res Protoc 2025;14:e74999