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Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbots are a highly accessible and scalable platform that allows for simulated conversations. Accessible via the web through a hyperlink or downloadable app, chatbots can be used on a smartphone, tablet, or computer. The use of chatbots has also been shown to improve access to services and support health equity by providing personalized health education, being available in multiple languages, and offering continuous access to information [11-15].

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

However, CDD has a distinct genetic cause and symptom profile, as severe developmental delay is exhibited from birth and seizure onset occurs earlier, and it was thus established as a separate clinical condition in 2013 [3-5]. CDD is caused by pathogenic variants in the X-linked gene CDKL5, which plays a key role in normal brain development and function [6].

Sam Amin, Carol-Anne Partridge, Helen Leonard, Jenny Downs, Helen Allvin, Valentine Ficara, Emilie Pain, Minna A Korolainen

JMIR Form Res 2025;9:e72489

Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data

Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data

To develop a more comprehensive understanding of these challenges, it is essential to analyze posts that involve multiple, overlapping themes and reflect the complexity of real-world experiences. We address this research gap by proposing a theme-driven framework that provides a labeled dataset. A comprehensive analysis is performed on this dataset, covering multiple themes of TINs and capturing Reddit post data from thousands of affected individuals.

Madhusudan Basak, Omar Sharif, Sarah E Lord, Jacob T Borodovsky, Lisa A Marsch, Sandra A Springer, Edward V Nunes, Charles D Brackett, Luke J Archibald, Sarah M Preum

J Med Internet Res 2025;27:e68886

Developing Infrastructure to Realize the Value of Patient-Generated Health Data in a Large Integrated Health Care System: The Veterans Health Administration Experience

Developing Infrastructure to Realize the Value of Patient-Generated Health Data in a Large Integrated Health Care System: The Veterans Health Administration Experience

As the PGHD database evolves and lessons are learned from researchers, field testers, and pilot projects, the goal will be to integrate PGHD into fundamental clinical workflows and build a knowledge base for where integration provides the greatest value. Data collected in the PGHD database are guided by a series of VHA policy and strategy documents, the development of which was overseen by the Office of Connected Care [9].

Terry J Newton, Nilesh Shah, Katherine Lewis, Mark S Zocchi, Felicia R Bixler, Bella Etingen, Jessica M Lipschitz, Stephanie A Robinson, Timothy P Hogan, Stephanie L Shimada

J Med Internet Res 2025;27:e70755

Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial

Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial

We conducted a feasibility randomized controlled trial to determine the acceptability of our m Health app [14]. A multipurpose m Health app can allow patients to monitor and track their pain, but additional features can increase app usage and engagement in their disease.

Robert M Cronin, Nives Quaye, Xin Liu, Kristina Landes, Lori E Crosby, Adetola A Kassim, Michael R DeBaun, Patrick M Schnell

JMIR Form Res 2025;9:e67906

Scaling a Brief Digital Well-Being Intervention (the Big Joy Project) and Sociodemographic Moderators: Single-Group Pre-Post Study

Scaling a Brief Digital Well-Being Intervention (the Big Joy Project) and Sociodemographic Moderators: Single-Group Pre-Post Study

In this paper, we test a brief, web-based well-being intervention, the Big Joy Project, on a large global sample to examine the impact of sociodemographic factors. Emotional well-being is a multidimensional composite that includes both the quality of momentary experiences and broader life judgments [7]. Emotional well-being is intimately associated with mental and physical health [4,5,11,12].

Darwin A Guevarra, Yoobin Park, Xuhai Xu, Jin Liou, Jolene Smith, Peggy Callahan, Emiliana Simon-Thomas, Elissa S Epel

J Med Internet Res 2025;27:e72053

Personal Health Record Software for Neuroendocrine Tumors: Patient-Centered Design Approach

Personal Health Record Software for Neuroendocrine Tumors: Patient-Centered Design Approach

In order for PHR software to successfully play a data gathering role for research studies it needs to provide a valuable service to patients, otherwise patients are less likely to use it [9,13]. Ideally, PHR software used for research studies would follow a model similar to that followed by free online services: users get a valuable service in exchange for their personal data.

Juan Pablo Hourcade, Michael O'Rorke, Elizabeth Chrischilles, Nicholas J Rudzianski, Brian Gryzlak, Kerry Peterman, Chris Ortman, Sam Wolstencroft, Margaret Bean, Elyse Gellerman, Josh A Mailman, Maryann Wahmann

JMIR Hum Factors 2025;12:e68788

A Novel Framework to Assess Clinical Information in Digital Health Technologies: Cross-Sectional Survey Study

A Novel Framework to Assess Clinical Information in Digital Health Technologies: Cross-Sectional Survey Study

An initial CLIQ framework was developed through a systematic review and qualitative synthesis of existing information quality frameworks for DHTs [11]. A CLIQ assessment questionnaire was then developed based on the CLIQ framework and further evidence from literature [21]. The questionnaire offers a pragmatic approach to assessing clinical information in DHTs based on relatable clinical scenarios.

Kayode Philip Fadahunsi, Petra A Wark, Nikolaos Mastellos, Ana Luisa Neves, Joseph Gallagher, Azeem Majeed, Josip Car

JMIR Med Inform 2025;13:e58125

Analyzing Trends in Suicidal Thoughts Among Patients With Psychosis in India: Exploratory Secondary Analysis of Smartphone Ecological Momentary Assessment Data

Analyzing Trends in Suicidal Thoughts Among Patients With Psychosis in India: Exploratory Secondary Analysis of Smartphone Ecological Momentary Assessment Data

Suicide is a common cause of premature mortality among people living with schizophrenia [3,4] and a recent systematic review has reported a point prevalence of nearly 30% of SIs in people with schizophrenia [5]. Most of the empirical research on the risks of suicidality includes cross-sectional or retrospective studies that distinguish the characteristics between people who experience SIs or suicidal behavior, and those who do not [6-8].

Ameya P Bondre, Aashish Ranjan, Ritu Shrivastava, Deepak Tugnawat, Nirmal Kumar Chaturvedi, Anant Bhan, Snehil Gupta, Abhijit R Rozatkar, Srilakshmi Nagendra, Siddharth Dutt, Soumya Choudhary, Preethi V Reddy, Urvakhsh Meherwan Mehta, John A Naslund, John Torous

JMIR Form Res 2025;9:e67745