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Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial

Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial

Ying et al [34] found that collateral puncture therapy can reduce the levels of interleukin-1 β, granulocyte-macrophage colony stimulating factor, tumor necrosis factor α, interleukin-6, and cyclooxygenase-2, while increasing the levels of interleukin-4 and interferon γ. This suggests that collateral puncture therapy enhances the levels of anti-inflammatory cytokines and inhibits the expression of pro-inflammatory cytokines, thereby exerting an anti-inflammatory effect.

Aolin Song, Bingnan Cui, Xuemin Wang, Jianing Bi, Xiaohong Wu, Liu Yang, Li Liu, Shengyuan Qu, Zhu Fan, Jiao Yang, Yuhe Yan

JMIR Res Protoc 2025;14:e59682