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The primary goal of aim 1 is to identify the most effective ATS among the 4 embedded strategies (A+B, A+C, D+E, or D+F, as shown in Table 2) that leads to the greatest reduction in STB. This aim focuses on finding the best-performing ATS rather than testing a hypothesis. The sample size of 480 was found to ensure an 80% probability of correctly identifying the ATS with the lowest mean outcome, assuming that such a strategy exists.
JMIR Res Protoc 2025;14:e68441
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