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Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

PGS is often conducted on a large scale, targeting asymptomatic individuals as part of public health initiatives. As a result, the communication typically emphasizes general risk awareness, with initial results disclosure indicating increased risk rather than confirming a diagnosis.

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

However, CDD has a distinct genetic cause and symptom profile, as severe developmental delay is exhibited from birth and seizure onset occurs earlier, and it was thus established as a separate clinical condition in 2013 [3-5]. CDD is caused by pathogenic variants in the X-linked gene CDKL5, which plays a key role in normal brain development and function [6].

Sam Amin, Carol-Anne Partridge, Helen Leonard, Jenny Downs, Helen Allvin, Valentine Ficara, Emilie Pain, Minna A Korolainen

JMIR Form Res 2025;9:e72489

Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data

Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data

To develop a more comprehensive understanding of these challenges, it is essential to analyze posts that involve multiple, overlapping themes and reflect the complexity of real-world experiences. We address this research gap by proposing a theme-driven framework that provides a labeled dataset. A comprehensive analysis is performed on this dataset, covering multiple themes of TINs and capturing Reddit post data from thousands of affected individuals.

Madhusudan Basak, Omar Sharif, Sarah E Lord, Jacob T Borodovsky, Lisa A Marsch, Sandra A Springer, Edward V Nunes, Charles D Brackett, Luke J Archibald, Sarah M Preum

J Med Internet Res 2025;27:e68886

Developing Infrastructure to Realize the Value of Patient-Generated Health Data in a Large Integrated Health Care System: The Veterans Health Administration Experience

Developing Infrastructure to Realize the Value of Patient-Generated Health Data in a Large Integrated Health Care System: The Veterans Health Administration Experience

As the PGHD database evolves and lessons are learned from researchers, field testers, and pilot projects, the goal will be to integrate PGHD into fundamental clinical workflows and build a knowledge base for where integration provides the greatest value. Data collected in the PGHD database are guided by a series of VHA policy and strategy documents, the development of which was overseen by the Office of Connected Care [9].

Terry J Newton, Nilesh Shah, Katherine Lewis, Mark S Zocchi, Felicia R Bixler, Bella Etingen, Jessica M Lipschitz, Stephanie A Robinson, Timothy P Hogan, Stephanie L Shimada

J Med Internet Res 2025;27:e70755

Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial

Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial

We conducted a feasibility randomized controlled trial to determine the acceptability of our m Health app [14]. A multipurpose m Health app can allow patients to monitor and track their pain, but additional features can increase app usage and engagement in their disease.

Robert M Cronin, Nives Quaye, Xin Liu, Kristina Landes, Lori E Crosby, Adetola A Kassim, Michael R DeBaun, Patrick M Schnell

JMIR Form Res 2025;9:e67906

A Training Program to Support Patient Engagement in Primary Health Care Research: Co-Design, Implementation, and Evaluation Study

A Training Program to Support Patient Engagement in Primary Health Care Research: Co-Design, Implementation, and Evaluation Study

They engaged a significant number of patients, caregivers, and citizens to provide input at the needs assessment stage of the project. An additional patient partner was a member of the Advisory Committee. To ensure that the program addressed existing knowledge gaps regarding patient-oriented research, we completed a needs assessment in 2 main steps to determine the learning needs of the targeted groups.

Amanda L Terry, Lorraine Bayliss, Leslie Meredith, Eugene Law, Rob Van Hoorn, Sandra Regan

J Particip Med 2025;17:e65485

Effectiveness of a Person-Centered and Culturally Sensitive Course of Treatment in Arabic-, Turkish-, and Urdu-Speaking Individuals With Type 2 Diabetes (the ACCT2 Study): Protocol for a Pragmatic Randomized Controlled Trial

Effectiveness of a Person-Centered and Culturally Sensitive Course of Treatment in Arabic-, Turkish-, and Urdu-Speaking Individuals With Type 2 Diabetes (the ACCT2 Study): Protocol for a Pragmatic Randomized Controlled Trial

The project worker will have a written informed consent ready to sign and be available to address any questions. Participants may have at least 24 hours to consider participation. A participant folder containing the written study information and the written informed consent will be handed to the potential participant, and a project worker will follow up with a phone call within a week.

Natasja Bjerre, Lene Christensen, Christina Hoeiberg, Cecilie Ottosson, Mie Klarskov Jensen, Nanna Kildsig, Trine Kjeldgaard Møller, Anne-Ditte Termannsen, Bettina Ewers, Britt Hollender-Schou, Rikke Molin Grue, Ulla Bjerre-Christensen, Solveig Jansen, Kamran Akram

JMIR Res Protoc 2025;14:e67319

Empowering Patients and Caregivers to Use Artificial Intelligence and Computer Vision for Wound Monitoring: Nonrandomized, Single-Arm Feasibility Study

Empowering Patients and Caregivers to Use Artificial Intelligence and Computer Vision for Wound Monitoring: Nonrandomized, Single-Arm Feasibility Study

The objective of this report is to present results of a feasibility study of early adopters of our patient-centric AI-powered wound assessment technology to image their wound to be included in their medical record and for self-monitoring, within 2 outpatient clinics in a university-affiliated hospital and a community hospital to determine overall feasibility, usability, and preliminary outcomes of the Patient Connect app.

Rose Raizman, José Luis Ramírez-GarciaLuna, Tanmoy Newaz, Sheila C Wang, Gregory K Berry, Ling Yuan Kong, Heba Tallah Mohammed, Robert D J Fraser

J Particip Med 2025;17:e69470

Scaling a Brief Digital Well-Being Intervention (the Big Joy Project) and Sociodemographic Moderators: Single-Group Pre-Post Study

Scaling a Brief Digital Well-Being Intervention (the Big Joy Project) and Sociodemographic Moderators: Single-Group Pre-Post Study

In this paper, we test a brief, web-based well-being intervention, the Big Joy Project, on a large global sample to examine the impact of sociodemographic factors. Emotional well-being is a multidimensional composite that includes both the quality of momentary experiences and broader life judgments [7]. Emotional well-being is intimately associated with mental and physical health [4,5,11,12].

Darwin A Guevarra, Yoobin Park, Xuhai Xu, Jin Liou, Jolene Smith, Peggy Callahan, Emiliana Simon-Thomas, Elissa S Epel

J Med Internet Res 2025;27:e72053