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Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

First-line laboratory screen: full blood count, C-reactive protein, renal, liver, and thyroid function tests, blood glucose, creatine phosphokinase, and iron measurement, and drug screen of urine. Repeated laboratory screening, as indicated by the treating physician. Tr: trial reduction of lorazepam. T0a: allocated treatment with lorazepam for 4 days. T0b: allocated treatment with sodium oxybate for 4 days after reduction of lorazepam.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356

The Added Value of Parents Practicing in Virtual Reality to Illustrate the Use of Innovative Methods in Parent-Child Interaction Therapy: Single-Case Experimental Design

The Added Value of Parents Practicing in Virtual Reality to Illustrate the Use of Innovative Methods in Parent-Child Interaction Therapy: Single-Case Experimental Design

Participants completed weekly measurements during a baseline phase (phase A, a minimum of 4, 5, or 6 measurements), an intervention period (phase B [PCIT] and phase B’ [PCIT with the addition of VR]), and a follow-up phase (phase C with 3 measurements) that took place 6 months posttreatment. Between phases, a more extensive measurement took place as a way to assess pretreatment, posttreatment, and follow-up group differences as well (Figure 1).

Iza C A Scherpbier, Mariëlle E Abrahamse, Samantha Bouwmeester, Robert G Belleman, Arne Popma, Ramón J L Lindauer

JMIR Pediatr Parent 2025;8:e60752

Grab Bar Grasp Location During Bathtub Exit and Sit-to-Stand Transfers: Biomechanical Evaluation

Grab Bar Grasp Location During Bathtub Exit and Sit-to-Stand Transfers: Biomechanical Evaluation

(C) Horizontal grab bar grasp locations during perturbation exits for HH and SH. (D) Vertical and horizontal grab bar grasp locations during STS. (E) Incline grab bar grasp locations during sit-to-stand. HH: high horizontal; LH: low horizontal; SH: standard horizontal; VRT: vertical.

Iris C Levine, Konika Nirmalanathan, Roger E Montgomery, Alison C Novak

JMIR Rehabil Assist Technol 2025;12:e69442

Development of a Cocreated Decision Aid for Patients With Depression—Combining Data-Driven Prediction With Patients’ and Clinicians’ Needs and Perspectives: Mixed Methods Study

Development of a Cocreated Decision Aid for Patients With Depression—Combining Data-Driven Prediction With Patients’ and Clinicians’ Needs and Perspectives: Mixed Methods Study

In cases with more than two measurements, the last score within 365 days was used (see Section C in Multimedia Appendix 1). Prediction modeling was based on validated Dutch OQ-45 cutoff scores to assess a clinically relevant decrease in symptoms between two measurements (reliable change index: a decrease of at least 14 points in total score) [45,47].

Kaying Kan, Frederike Jörg, Klaas J Wardenaar, Frank J Blaauw, Maarten F Brilman, Ellen Visser, Dennis Raven, Dwayne Meijnckens, Erik Buskens, Danielle C Cath, Bennard Doornbos, Robert A Schoevers, Talitha L Feenstra

J Particip Med 2025;17:e67170

Evaluating the Effectiveness of an Intelligent mHealth Intervention for Child Unintentional Injury Prevention: Protocol for a Cluster Randomized Controlled Trial

Evaluating the Effectiveness of an Intelligent mHealth Intervention for Child Unintentional Injury Prevention: Protocol for a Cluster Randomized Controlled Trial

Data will be de-identified before analysis, and no personally identifiable information will be retained in the analytic dataset. Participants will receive a modest digital monetary incentive ranging from 5 to 50 Chinese Yuan through a lottery-based mechanism via We Chat for their time and participation. No identifiable information will be included in the manuscript or any supplementary materials. The study received funding in January 2023.

Yang Yuan, Yuying Jing, Jiyu Li, Jieyi He, David C Schwebel, Peishan Ning, Zhenzhen Rao, Li Li, Guoqing Hu

JMIR Public Health Surveill 2025;11:e76195

Performance of Machine Learning in Diagnosing KRAS (Kirsten Rat Sarcoma) Mutations in Colorectal Cancer: Systematic Review and Meta-Analysis

Performance of Machine Learning in Diagnosing KRAS (Kirsten Rat Sarcoma) Mutations in Colorectal Cancer: Systematic Review and Meta-Analysis

In the CRC training cohort, 36 models reported the c-index effect size for isolated KRAS mutations, with 34 models providing data directly extractable or indirectly calculable through 2*2 diagnostic tables. The c-index of models based on clinical characteristics was 0.69 (95% CI 0.68‐0.70), with sensitivity and specificity ranging from 0.66 to 0.79 and 0.57 to 0.58.

Kaixin Chen, Yin Qu, Ye Han, Yan Li, Huiyan Gao, De Zheng

J Med Internet Res 2025;27:e73528