<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Med Educ</journal-id><journal-id journal-id-type="publisher-id">mededu</journal-id><journal-id journal-id-type="index">20</journal-id><journal-title>JMIR Medical Education</journal-title><abbrev-journal-title>JMIR Med Educ</abbrev-journal-title><issn pub-type="epub">2369-3762</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v11i1e71721</article-id><article-id pub-id-type="doi">10.2196/71721</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter to the Editor</subject></subj-group></article-categories><title-group><article-title>Authors&#x2019; Reply: Enhancing AI-Driven Medical Translations: Considerations for Language Concordance</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Teng</surname><given-names>Joyce</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Novoa</surname><given-names>Roberto Andres</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Aleshin</surname><given-names>Maria Alexandrovna</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Lester</surname><given-names>Jenna</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Seiger</surname><given-names>Kira</given-names></name><degrees>MD, MBA</degrees><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Dzuali</surname><given-names>Fiatsogbe</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Daneshjou</surname><given-names>Roxana</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Dermatology, Stanford University</institution><addr-line>700 Welch Rd</addr-line><addr-line>Stanford</addr-line><country>United States</country></aff><aff id="aff2"><institution>Department of Pathology, Stanford University</institution><addr-line>Redwood City</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff3"><institution>Department of Dermatology, University of California</institution><addr-line>San Francisco</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff4"><institution>Department of Dermatology, University of Washington</institution><addr-line>Seattle</addr-line><addr-line>WA</addr-line><country>United States</country></aff><aff id="aff5"><institution>Department of Biomedical Data Science, Stanford University</institution><addr-line>Stanford</addr-line><addr-line>CA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Leung</surname><given-names>Tiffany</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Joyce Teng, MD, PhD, Department of Dermatology, Stanford University, 700 Welch Rd, Stanford, 94305, United States, 1 6507236493; <email>jteng3@stanford.edu</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>11</day><month>4</month><year>2025</year></pub-date><volume>11</volume><elocation-id>e71721</elocation-id><history><date date-type="received"><day>24</day><month>01</month><year>2025</year></date><date date-type="rev-recd"><day>26</day><month>01</month><year>2025</year></date><date date-type="accepted"><day>27</day><month>01</month><year>2025</year></date></history><copyright-statement>&#x00A9; Joyce Teng, Roberto Andres Novoa, Maria Alexandrovna Aleshin, Jenna Lester, Kira Seiger, Fiatsogbe Dzuali, Roxana Daneshjou. Originally published in JMIR Medical Education (<ext-link ext-link-type="uri" xlink:href="https://mededu.jmir.org">https://mededu.jmir.org</ext-link>), 11.4.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Education, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://mededu.jmir.org/">https://mededu.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://mededu.jmir.org/2025/1/e71721"/><related-article related-article-type="commentary article" ext-link-type="doi" xlink:href="10.2196/51435" xlink:title="Comment on" xlink:type="simple">https://mededu.jmir.org/2024/1/e51435</related-article><related-article related-article-type="commentary" ext-link-type="doi" xlink:href="10.2196/70420" xlink:title="Comment in" xlink:type="simple">https://mededu.jmir.org/2025/1/e70420</related-article><kwd-group><kwd>ChatGPT</kwd><kwd>artificial intelligence</kwd><kwd>language</kwd><kwd>translation</kwd><kwd>health care disparity</kwd><kwd>natural language model</kwd><kwd>survey</kwd><kwd>patient education</kwd><kwd>accessibility</kwd><kwd>preference</kwd><kwd>human language</kwd><kwd>communication</kwd><kwd>language-concordant care</kwd></kwd-group></article-meta></front><body><p>We appreciate the thoughtful insights shared by Quon and Zhou [<xref ref-type="bibr" rid="ref1">1</xref>] regarding our study on the application of ChatGPT in translating patient education materials [<xref ref-type="bibr" rid="ref2">2</xref>]. We wholly agree that the linguistically distinct languages, such as Mandarin, can present challenges in capturing all the nuances and achieving precise translations.</p><p>In response to the comment regarding the use of multiple prompts, we acknowledge the complexity and variability in artificial intelligence (AI)-generated translations. However, it is important to consider the practical limitations within a clinical setting. Asking providers to use various prompts in real time may not be feasible due to time constraints and the need for efficiency in patient care. We believe that focusing on a single, effective prompt can streamline the translation process while we explore avenues for improvement in the AI&#x2019;s capabilities. This could be a productive avenue for future research.</p><p>Addressing the concern regarding the reliance on board-certified dermatologists for post-translation review, we want to clarify that, in addition to being board-certified dermatologists, all reviewers were native speakers in the language they reviewed, including fluency in Mandarin at a college level. This proficiency allows for a confluence of both clinical and linguistic insights when evaluating translations, reinforcing the validity of our findings. We appreciate the importance of rigor in translation review and remain committed to enhancing the integrity of our translated materials.</p><p>Overall, while we recognize the areas where ChatGPT can improve, we also see its current utility as a valuable tool for expanding access to language-concordant care in clinical settings. Our study serves as a helpful step toward identifying and addressing the limitations of AI translations, and we welcome continued dialogue to refine these practices.</p></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AI</term><def><p>artificial intelligence</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Quon</surname><given-names>S</given-names> </name><name name-style="western"><surname>Zhou</surname><given-names>S</given-names> </name></person-group><article-title>Enhancing AI-driven medical translations: considerations for language concordance</article-title><source>JMIR Med Educ</source><year>2025</year><volume>11</volume><pub-id pub-id-type="doi">10.2196/70420</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Dzuali</surname><given-names>F</given-names> </name><name name-style="western"><surname>Seiger</surname><given-names>K</given-names> </name><name name-style="western"><surname>Novoa</surname><given-names>R</given-names> </name><etal/></person-group><article-title>ChatGPT may improve access to language-concordant care for patients with non-English language preferences</article-title><source>JMIR Med Educ</source><year>2024</year><month>12</month><day>10</day><volume>10</volume><fpage>e51435</fpage><pub-id pub-id-type="doi">10.2196/51435</pub-id><pub-id pub-id-type="medline">39657144</pub-id></nlm-citation></ref></ref-list></back></article>