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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JME</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Med Educ</journal-id>
      <journal-title>JMIR Medical Education</journal-title>
      <issn pub-type="epub">2369-3762</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v8i2e38259</article-id>
      <article-id pub-id-type="pmid">35767323</article-id>
      <article-id pub-id-type="doi">10.2196/38259</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Usability Methods and Attributes Reported in Usability Studies of Mobile Apps for Health Care Education: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Leung</surname>
            <given-names>Tiffany</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Rutter</surname>
            <given-names>Lauren</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Mehdizadeh</surname>
            <given-names>Hamed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Gutierrez-Puertas</surname>
            <given-names>Lorena</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>Johnson</surname>
            <given-names>Susanne Grødem</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Faculty of Health and Function</institution>
            <institution>Western Norway University of Applied Sciences</institution>
            <addr-line>Inndalsveien 28</addr-line>
            <addr-line>Bergen, 5063</addr-line>
            <country>Norway</country>
            <phone>47 92213202</phone>
            <email>susanne.grodem.johnson@hvl.no</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2500-8952</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Potrebny</surname>
            <given-names>Thomas</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1487-0560</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Larun</surname>
            <given-names>Lillebeth</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2012-7116</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Ciliska</surname>
            <given-names>Donna</given-names>
          </name>
          <degrees>Prof Dr</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7124-4895</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Olsen</surname>
            <given-names>Nina Rydland</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-5173-1597</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Faculty of Health and Function</institution>
        <institution>Western Norway University of Applied Sciences</institution>
        <addr-line>Bergen</addr-line>
        <country>Norway</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Division of Health Services</institution>
        <institution>Norwegian Institute of Public Health</institution>
        <addr-line>Oslo</addr-line>
        <country>Norway</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Faculty of Health Sciences</institution>
        <institution>McMaster University</institution>
        <addr-line>Hamilton, ON</addr-line>
        <country>Canada</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Susanne Grødem Johnson <email>susanne.grodem.johnson@hvl.no</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <season>Apr-Jun</season>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>29</day>
        <month>6</month>
        <year>2022</year>
      </pub-date>
      <volume>8</volume>
      <issue>2</issue>
      <elocation-id>e38259</elocation-id>
      <history>
        <date date-type="received">
          <day>25</day>
          <month>3</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>12</day>
          <month>5</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>2</day>
          <month>6</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>5</day>
          <month>6</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Susanne Grødem Johnson, Thomas Potrebny, Lillebeth Larun, Donna Ciliska, Nina Rydland Olsen. Originally published in JMIR Medical Education (https://mededu.jmir.org), 29.06.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Education, is properly cited. The complete bibliographic information, a link to the original publication on https://mededu.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mededu.jmir.org/2022/2/e38259" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Mobile devices can provide extendable learning environments in higher education and motivate students to engage in adaptive and collaborative learning. Developers must design mobile apps that are practical, effective, and easy to use, and usability testing is essential for understanding how mobile apps meet users’ needs. No previous reviews have investigated the usability of mobile apps developed for health care education.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The aim of this scoping review is to identify usability methods and attributes in usability studies of mobile apps for health care education.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A comprehensive search was carried out in 10 databases, reference lists, and gray literature. Studies were included if they dealt with health care students and usability of mobile apps for learning. Frequencies and percentages were used to present the nominal data, together with tables and graphical illustrations. Examples include a figure of the study selection process, an illustration of the frequency of inquiry usability evaluation and data collection methods, and an overview of the distribution of the identified usability attributes. We followed the Arksey and O’Malley framework for scoping reviews.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Our scoping review collated 88 articles involving 98 studies, mainly related to medical and nursing students. The studies were conducted from 22 countries and were published between 2008 and 2021. Field testing was the main usability experiment used, and the usability evaluation methods were either inquiry-based or based on user testing. Inquiry methods were predominantly used: 1-group design (46/98, 47%), control group design (12/98, 12%), randomized controlled trials (12/98, 12%), mixed methods (12/98, 12%), and qualitative methods (11/98, 11%). User testing methods applied were all think aloud (5/98, 5%). A total of 17 usability attributes were identified; of these, satisfaction, usefulness, ease of use, learning performance, and learnability were reported most frequently. The most frequently used data collection method was questionnaires (83/98, 85%), but only 19% (19/98) of studies used a psychometrically tested usability questionnaire. Other data collection methods included focus group interviews, knowledge and task performance testing, and user data collected from apps, interviews, written qualitative reflections, and observations. Most of the included studies used more than one data collection method.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Experimental designs were the most commonly used methods for evaluating usability, and most studies used field testing. Questionnaires were frequently used for data collection, although few studies used psychometrically tested questionnaires. The usability attributes identified most often were satisfaction, usefulness, and ease of use. The results indicate that combining different usability evaluation methods, incorporating both subjective and objective usability measures, and specifying which usability attributes to test seem advantageous. The results can support the planning and conduct of future usability studies for the advancement of mobile learning apps in health care education.</p>
        </sec>
        <sec sec-type="registered-report">
          <title>International Registered Report Identifier (IRRID)</title>
          <p>RR2-10.2196/19072</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>user-computer interface</kwd>
        <kwd>mobile apps</kwd>
        <kwd>online learning</kwd>
        <kwd>health education</kwd>
        <kwd>students</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Mobile devices can provide extendable learning environments and motivate students to engage in adaptive and collaborative learning [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. Mobile devices offer various functions, enable convenient access, and support the ability to share information with other learners and teachers [<xref ref-type="bibr" rid="ref3">3</xref>]. Most students own a mobile phone, which makes mobile learning easily accessible [<xref ref-type="bibr" rid="ref4">4</xref>]. However, there are some challenges associated with mobile devices in learning situations, such as small screen sizes, connectivity problems, and multiple distractions in the environment [<xref ref-type="bibr" rid="ref5">5</xref>].</p>
        <p>Developers of mobile learning apps need to consider usability to ensure that apps are practical, effective, and easy to use [<xref ref-type="bibr" rid="ref1">1</xref>] and to ascertain that mobile apps meet users’ needs [<xref ref-type="bibr" rid="ref6">6</xref>]. According to the International Organization for Standardization, usability is defined as “the extent to which a system, product or service can be used by specified users to achieve specified goals with effectiveness, efficiency, and satisfaction in a specified context of use” [<xref ref-type="bibr" rid="ref7">7</xref>]. Better mobile learning usability will be achieved by focusing on user-centered design and attention to context, ensuring that the technology corresponds to the user’s requirements and putting the user at the center of the process [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. In addition, it is necessary to be conscious of the interrelatedness between usability and pedagogical design [<xref ref-type="bibr" rid="ref9">9</xref>].</p>
        <p>A variety of usability evaluation methods exists to test the usability of mobile apps, and Weichbroth [<xref ref-type="bibr" rid="ref10">10</xref>] categorized them into the following 4 categories: inquiry, user testing, inspection, and analytical modeling. Inquiry methods are designed to gather data from users through questionnaires (quantitative data) and interviews and focus groups (qualitative data). User testing methods include think-aloud protocols, question-asking protocols, performance measurements, log analysis, eye tracking, and remote testing. Inspection methods, in contrast, involve experts testing apps, heuristic evaluation, cognitive walk-through, perspective-based inspections, and guideline reviews. Analytical modeling methods include cognitive task analysis and task environment analysis [<xref ref-type="bibr" rid="ref10">10</xref>]. Across these 4 usability evaluation methods, the most commonly used data collection methods are controlled observations and surveys, whereas eye tracking, think-aloud methods, and interviews are applied less often [<xref ref-type="bibr" rid="ref10">10</xref>].</p>
        <p>Usability evaluations are normally performed in a laboratory or in field testing. Previous reviews have reported that usability evaluation methods are mainly conducted in a laboratory, which means in a controlled environment [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. By contrast, field testing is conducted in real-life settings. There are pros and cons to the 2 different approaches. Field testing allows data collection within a dynamic environment, whereas in a laboratory data collection and conditions are easier to control [<xref ref-type="bibr" rid="ref1">1</xref>]. A variety of data collection methods are appropriate for usability studies; for instance, in laboratories, participants performing predefined tasks, such as using questionnaires and observations, are often applied [<xref ref-type="bibr" rid="ref1">1</xref>]. In field testing, logging mechanisms and diaries have been applied to capture user interaction with mobile apps [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
        <p>In all, 2 systematic reviews examined various psychometrically tested usability questionnaires as a means of enhancing the usability of apps. Sousa and Lopez [<xref ref-type="bibr" rid="ref12">12</xref>] identified 15 such questionnaires and Sure [<xref ref-type="bibr" rid="ref13">13</xref>] identified 13. In all, 5 of the questionnaires have proven to be applicable in usability studies in general: the System Usability Scale (SUS), Questionnaire for User Interaction Satisfaction, After-Scenario Questionnaire, Post-Study System Usability Questionnaire, and Computer System Usability Questionnaire [<xref ref-type="bibr" rid="ref12">12</xref>]. The SUS questionnaire and After-Scenario Questionnaire are most widely applied [<xref ref-type="bibr" rid="ref13">13</xref>]. The most frequently reported usability attributes of these 5 questionnaires are learnability, efficiency, and satisfaction [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        <p>Usability attributes are features that measure the quality of mobile apps [<xref ref-type="bibr" rid="ref1">1</xref>]. The most commonly reported usability attributes are effectiveness, efficiency, and satisfaction [<xref ref-type="bibr" rid="ref5">5</xref>], which are part of the usability definition [<xref ref-type="bibr" rid="ref7">7</xref>]. In the review by Weichbroth [<xref ref-type="bibr" rid="ref10">10</xref>], 75 different usability attributes were identified. Given the wide selection of usability attributes, choosing appropriate attributes depends on the nature of the technology and the research question in the usability study [<xref ref-type="bibr" rid="ref14">14</xref>]. Kumar and Mohite [<xref ref-type="bibr" rid="ref1">1</xref>] recommended that researchers present and explain which usability attributes are being tested when mobile apps are being developed.</p>
        <p>Previous reviews have examined the usability of mobile apps in general [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]; however, only one systematic review has specifically explored the usability of mobile learning apps [<xref ref-type="bibr" rid="ref1">1</xref>]. However, studies from health care education were not included. Similarly, usability has not been widely explored in medical education apps [<xref ref-type="bibr" rid="ref16">16</xref>]. Thus, there is a need to develop a better understanding of how the usability of mobile learning apps developed for health care education has been evaluated and conceptualized in previous studies.</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>The aim of this scoping review has therefore been to identify usability methods and attributes in usability studies of mobile apps for health care education.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Framework</title>
        <p>We have used the framework for scoping reviews developed by Arksey and O'Malley [<xref ref-type="bibr" rid="ref17">17</xref>] and further developed by Levac et al [<xref ref-type="bibr" rid="ref18">18</xref>] and Khalil et al [<xref ref-type="bibr" rid="ref19">19</xref>]. We adopted the following five stages of this framework: (1) identifying the research question, (2) identifying relevant studies, (3) selecting studies, (4) charting the data, and (5) summarizing and reporting the results [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref19">19</xref>]. A detailed presentation of each step can be found in the published protocol for this scoping review [<xref ref-type="bibr" rid="ref20">20</xref>]. We followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist for reporting scoping reviews (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> [<xref ref-type="bibr" rid="ref21">21</xref>]).</p>
      </sec>
      <sec>
        <title>Stage 1: Identifying the Research Question</title>
        <p>The following two research questions have been formulated:</p>
        <list list-type="order">
          <list-item>
            <p>Which usability methods are used to evaluate the usability of mobile apps for health care education?</p>
          </list-item>
          <list-item>
            <p>Which usability attributes are reported in the usability studies of mobile apps for health care education?</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title>Stage 2: Identifying Relevant Studies</title>
        <p>A total of 10 electronic databases on technology, education, and health care from January 2008 to October 2021 and February 2022 were searched. These databases were as follows: Engineering Village, Scopus, ACM Digital Library, IEEE Xplore, Education Resource Information Center, PsycINFO, CINAHL, MEDLINE, EMBASE, and Web of Science. The search string was developed by the first author and a research librarian and then peer reviewed by another research librarian. The search terms used in the Web of Science, in addition to all relevant subject headings, included: <italic>((student* or graduate* or undergraduate* or postgraduate*) NEAR/3 nurs*)</italic>. This search string was repeated for other types of students and combined with the Boolean operator OR. The search string for all types of health care students was then combined with various search terms for mobile apps and mobile learning using the Boolean operator AND. Similar search strategies were used and adapted for all 10 databases as shown in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. In addition, a citation search in Google Scholar, screening reference lists of included studies, and searching for gray literature in OpenGrey were conducted.</p>
      </sec>
      <sec>
        <title>Stage 3: Selecting Studies</title>
        <p>Two of the authors independently screened titles and abstracts using Rayyan web-based management software [<xref ref-type="bibr" rid="ref22">22</xref>]. Studies deemed eligible by one of the authors were included for full-text screening and imported into the EndNote X9 (Clarivate) reference management system [<xref ref-type="bibr" rid="ref23">23</xref>]. Eligibility for full-text screening was determined independently by two of the authors and disagreements were resolved by consensus-based discussions. Research articles with different designs were included, and there were no language restrictions. As mobile apps started appearing in 2008, this year was set as the starting point for the search. Eligibility criteria are presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Study eligibility.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="130"/>
            <col width="440"/>
            <col width="430"/>
            <thead>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Inclusion criteria</td>
                <td>Exclusion criteria</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Population</td>
                <td>Health care and allied health care students at the undergraduate and postgraduate levels</td>
                <td>Health care professionals or students from education, engineering, or other nonhealth sciences</td>
              </tr>
              <tr valign="top">
                <td>Concept</td>
                <td>Studies of usability testing or methods of usability evaluation of mobile learning apps where the purpose relates to the development of the apps</td>
                <td>Studies relating to learner management systems, e-learning platforms, open online courses, or distance education</td>
              </tr>
              <tr valign="top">
                <td>Context</td>
                <td>Typical educational setting (eg, classroom teaching, clinical placement, or simulation training), including both synchronous and asynchronous teaching</td>
                <td>Noneducational settings not involving clinical placement or learning situations (eg, hospital or community settings)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Stage 4: Charting the Data (Data Abstraction)</title>
        <p>The extracted data included information about the study (eg, authors, year of publication, title, and country), population (eg, number of participants), concepts (usability methods, usability attributes, and usability phase), and context (educational setting). The final data extraction sheet can be found in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref111">111</xref>]. One review author extracted the data from the included studies using Microsoft Excel software [<xref ref-type="bibr" rid="ref21">21</xref>], which was checked by another researcher.</p>
        <p>Descriptions of usability attributes have not been standardized, making categorization challenging. Therefore, a review author used deductive analysis to interpret the usability attributes reported in the included studies. This interpretation was based on a review of usability attributes as defined in previous literature. These definitions were assessed on the basis of the results of the included studies. This analysis was reviewed and discussed by another author. Disagreements were resolved through a consensus-based discussion.</p>
      </sec>
      <sec>
        <title>Stage 5: Summarizing and Reporting the Results</title>
        <p>Frequencies and percentages were used to present nominal data, together with tables and graphical illustrations. For instance, a figure showing the study selection process, an illustration of the frequency of inquiry-based usability evaluation and data collection methods, and an overview of the distribution of identified usability attributes were provided.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Eligible Studies</title>
        <p>Database searches yielded 34,369 records, and 2796 records were identified using other methods. After removing duplicates, 28,702 records remained. A total of 626 reports were examined in full text. In all, 88 articles were included in the scoping review [<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref111">111</xref>] (<xref rid="figure1" ref-type="fig">Figure 1</xref>). A total of 8 articles comprised results from several studies in the same article, presented as study A, study B, or study C in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>. Therefore, a total of 98 studies were reported in the 88 articles included.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart of study selection process.</p>
          </caption>
          <graphic xlink:href="mededu_v8i2e38259_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>The included studies comprised a total sample population of 7790, with participant numbers ranging from 5 to 736 participants per study. Most of the studies included medical students (34/88, 39%) or nursing students (25/88, 28%). Other participants included students from the following disciplines: pharmacy (9/88, 10%), dentistry (5/88, 6%), physiotherapy (5/88, 6%), health sciences (3/88, 3%), and psychology (2/88, 2%). Further information is provided in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>. There were 22 publishing countries, with most studies being from the United States (22/88, 25%), Spain (9/88, 10%), the United Kingdom (8/88, 9%), Canada (7/88, 8%), and Brazil (7/88, 8%), with an increasing number of publications from 2014. <xref ref-type="table" rid="table2">Table 2</xref> provides an overview and characteristics of the included articles.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Characteristics of included articles.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="120"/>
            <col width="240"/>
            <col width="180"/>
            <col width="250"/>
            <col width="210"/>
            <thead>
              <tr valign="top">
                <td>Study number</td>
                <td>Study</td>
                <td>Population (N)</td>
                <td>Research design: data collection method</td>
                <td>Usability attributes</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>1</td>
                <td>Aebersold et al [<xref ref-type="bibr" rid="ref24">24</xref>], 2018, United States</td>
                <td>Nursing (N=69)</td>
                <td>Mixed methods: questionnaire; task and knowledge performance<sup>a</sup></td>
                <td>Ease of use; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>2</td>
                <td>Akl et al [<xref ref-type="bibr" rid="ref25">25</xref>], 2008, United States</td>
                <td>Resident (N=30)</td>
                <td>Qualitative methods: focus groups; written qualitative reflections</td>
                <td>Satisfaction</td>
              </tr>
              <tr valign="top">
                <td>3</td>
                <td>Al-Rawi et al [<xref ref-type="bibr" rid="ref26">26</xref>], 2015, United States</td>
                <td>Dentist (N=61)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; frequency of use; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>4</td>
                <td>Albrecht et al [<xref ref-type="bibr" rid="ref27">27</xref>], 2013, Germany</td>
                <td>Medicine (N=6)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Satisfaction</td>
              </tr>
              <tr valign="top">
                <td>5</td>
                <td>Alencar Neto et al [<xref ref-type="bibr" rid="ref28">28</xref>], 2020, Brazil</td>
                <td>Medicine (N=132)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Ease of use; learnability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>6</td>
                <td>Alepis and Virvou [<xref ref-type="bibr" rid="ref29">29</xref>], 2010, Greece</td>
                <td>Medicine (N=110)</td>
                <td>Mixed methods: questionnaire; interviews</td>
                <td>Ease of use; usefulness; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>7</td>
                <td>Ameri et al [<xref ref-type="bibr" rid="ref30">30</xref>], 2020, Iran</td>
                <td>Pharmacy (N=241)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Context of use; efficiency; usefulness</td>
              </tr>
              <tr valign="top">
                <td>8</td>
                <td>Balajelini and Ghezeljeh [<xref ref-type="bibr" rid="ref31">31</xref>], 2018, Iran</td>
                <td>Nursing (N=41)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; frequency of use; navigation; satisfaction; simplicity; usefulness</td>
              </tr>
              <tr valign="top">
                <td>9</td>
                <td>Barnes et al [<xref ref-type="bibr" rid="ref32">32</xref>], 2015, United Kingdom</td>
                <td>Medicine (N=42)</td>
                <td>Randomized controlled trial: questionnaire; task and knowledge performance</td>
                <td>Ease of use; effectiveness; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>10</td>
                <td>Busanello et al [<xref ref-type="bibr" rid="ref33">33</xref>], 2015, Brazil</td>
                <td>Dentist (N=62)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire<sup>b</sup></td>
                <td>Learnability; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>11</td>
                <td>Cabero-Almenara and Roig-Vila [<xref ref-type="bibr" rid="ref34">34</xref>], 2019, Spain</td>
                <td>Medicine (N=50)</td>
                <td>Pre-post test, 1-group design: questionnaire<sup>b</sup></td>
                <td>Learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>12</td>
                <td>Choi et al [<xref ref-type="bibr" rid="ref35">35</xref>], 2015, South Korea</td>
                <td>Nursing (N=5)</td>
                <td>Think-aloud methods: interviews; data from app</td>
                <td>Context of use; ease of use; learnability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>13</td>
                <td>Choi et al [<xref ref-type="bibr" rid="ref36">36</xref>], 2018, South Korea</td>
                <td>Nursing (N=75)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire</td>
                <td>Ease of use; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>14</td>
                <td>Choo et al [<xref ref-type="bibr" rid="ref37">37</xref>], 2019, Singapore</td>
                <td>Psychology (N=8)</td>
                <td>Mixed methods: questionnaire<sup>b</sup>; written qualitative reflections</td>
                <td>Ease of use; learning performance; satisfaction; usefulness; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>15</td>
                <td>Chreiman et al [<xref ref-type="bibr" rid="ref38">38</xref>], 2017, United States</td>
                <td>Medicine (N=30)</td>
                <td>Posttest 1-group design: questionnaire; data from app</td>
                <td>Context of use; ease of use; frequency of use; usefulness</td>
              </tr>
              <tr valign="top">
                <td>16</td>
                <td>Colucci et al [<xref ref-type="bibr" rid="ref39">39</xref>], 2015, United States</td>
                <td>Medicine (N=115)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Effectiveness; efficiency; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>17</td>
                <td>Davids et al [<xref ref-type="bibr" rid="ref40">40</xref>], 2014, South Africa</td>
                <td>Residents (N=82)</td>
                <td>Randomized controlled trial: questionnaire<sup>b</sup>; data from app</td>
                <td>Effectiveness; efficiency; learnability; navigation; satisfaction; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>18A</td>
                <td>Demmans et al [<xref ref-type="bibr" rid="ref41">41</xref>], 2018, Canada</td>
                <td>Nursing (N=60)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire; observations</td>
                <td>Ease of use; effectiveness; learnability; learning performance; navigation; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>18B</td>
                <td>Demmans et al [<xref ref-type="bibr" rid="ref41">41</xref>], 2018, Canada</td>
                <td>Nursing (N=85)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire; observations</td>
                <td>Ease of use; effectiveness; learnability; learning performance; navigation; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>19</td>
                <td>Devraj et al [<xref ref-type="bibr" rid="ref42">42</xref>], 2021, United States</td>
                <td>Pharmacy (N=89)</td>
                <td>Posttest 1-group design: questionnaire; data from app</td>
                <td>Ease of use; errors; frequency of use; learning performance; navigation; operational usability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>20</td>
                <td>Díaz-Fernández et al [<xref ref-type="bibr" rid="ref43">43</xref>], 2016, Spain</td>
                <td>Physiotherapy (N=110)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Comprehensibility; ease of use; usefulness</td>
              </tr>
              <tr valign="top">
                <td>21</td>
                <td>Docking et al [<xref ref-type="bibr" rid="ref44">44</xref>], 2018, United Kingdom</td>
                <td>Paramedic (N=24)</td>
                <td>Think-aloud methods: focus groups</td>
                <td>Context of use; learnability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>22</td>
                <td>Dodson and Baker [<xref ref-type="bibr" rid="ref45">45</xref>], 2020, United States</td>
                <td>Nursing (N=23)</td>
                <td>Qualitative methods: focus groups</td>
                <td>Ease of use; operational usability; satisfaction; usefulness; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>23</td>
                <td>Duarte Filho et al [<xref ref-type="bibr" rid="ref46">46</xref>], 2014, Brazil</td>
                <td>Medicine (N=10)</td>
                <td>Posttest nonrandomized control group design: questionnaire</td>
                <td>Ease of use; efficiency; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>24</td>
                <td>Duggan et al [<xref ref-type="bibr" rid="ref47">47</xref>], 2020, Canada</td>
                <td>Medicine (N=80)</td>
                <td>Posttest 1-group design: questionnaire; data from app</td>
                <td>Ease of use; frequency of use; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>25</td>
                <td>Fernandez-Lao et al [<xref ref-type="bibr" rid="ref48">48</xref>], 2016, Spain</td>
                <td>Physiotherapy (N=49)</td>
                <td>Randomized controlled trial: questionnaire<sup>b</sup>; task and knowledge performance</td>
                <td>Learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>26</td>
                <td>Fralick et al [<xref ref-type="bibr" rid="ref49">49</xref>], 2017, Canada</td>
                <td>Medicine (N=62)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire</td>
                <td>Ease of use; frequency of use; learning performance; usefulness</td>
              </tr>
              <tr valign="top">
                <td>27</td>
                <td>Ghafari et al [<xref ref-type="bibr" rid="ref50">50</xref>], 2020, Iran</td>
                <td>Nursing (N=8)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; operational usability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>28</td>
                <td>Goldberg et al [<xref ref-type="bibr" rid="ref51">51</xref>], 2014, United States</td>
                <td>Medicine (N=18)</td>
                <td>Posttest 1-group design: questionnaire; task and knowledge performance</td>
                <td>Ease of use; effectiveness</td>
              </tr>
              <tr valign="top">
                <td>29</td>
                <td>Gutiérrez-Puertas et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2021, Spain</td>
                <td>Nursing (N=184)</td>
                <td>Randomized controlled trial: questionnaire; task and knowledge performance</td>
                <td>Learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>30</td>
                <td>Herbert et al [<xref ref-type="bibr" rid="ref53">53</xref>], 2021, United States</td>
                <td>Nursing (N=33)</td>
                <td>Randomized controlled trial: questionnaire; task and knowledge performance</td>
                <td>Ease of use; learning performance; navigation; operational usability; usefulness</td>
              </tr>
              <tr valign="top">
                <td>31</td>
                <td>Hsu et al [<xref ref-type="bibr" rid="ref54">54</xref>], 2019, Taiwan</td>
                <td>Nursing (N=16)</td>
                <td>Qualitative methods: interviews</td>
                <td>Context of use; operational usability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>32</td>
                <td>Huang et al [<xref ref-type="bibr" rid="ref55">55</xref>], 2010, Taiwan</td>
                <td>Not clear (N=28)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; satisfaction, usefulness</td>
              </tr>
              <tr valign="top">
                <td>33</td>
                <td>Hughes and Kearney [<xref ref-type="bibr" rid="ref56">56</xref>], 2017, United States</td>
                <td>Occupational therapy (N=19)</td>
                <td>Qualitative methods: focus groups</td>
                <td>Efficiency; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>34</td>
                <td>Ismail et al [<xref ref-type="bibr" rid="ref57">57</xref>], 2018, Malaysia</td>
                <td>Health science (N=124)</td>
                <td>Pre-post test, 1-group design: questionnaire</td>
                <td>Ease of use; learning performance; satisfaction; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>35</td>
                <td>Johnson et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2021, Norway</td>
                <td>Occupational therapy, physiotherapy, and social education (N=15)</td>
                <td>Qualitative methods: focus groups</td>
                <td>Context of use; ease of use; operational usability</td>
              </tr>
              <tr valign="top">
                <td>36A</td>
                <td>Kang Suh [<xref ref-type="bibr" rid="ref59">59</xref>], 2018, South Korea</td>
                <td>Nursing (N=92)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire; data from app</td>
                <td>Effectiveness; frequency of use; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>36B</td>
                <td>Kang Suh [<xref ref-type="bibr" rid="ref59">59</xref>], 2018, South Korea</td>
                <td>Nursing (N=49)</td>
                <td>Qualitative methods: focus groups</td>
                <td>Effectiveness; frequency of use; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>37</td>
                <td>Keegan et al [<xref ref-type="bibr" rid="ref60">60</xref>], 2016, United States</td>
                <td>Nursing (N=116)</td>
                <td>Posttest nonrandomized control group design: questionnaire; task and knowledge performance</td>
                <td>Learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>38</td>
                <td>Kim-Berman et al [<xref ref-type="bibr" rid="ref61">61</xref>], 2019, United States</td>
                <td>Dentist (N=93)</td>
                <td>Posttest 1-group design: questionnaire; task and knowledge performance</td>
                <td>Context of use; ease of use; effectiveness; usefulness</td>
              </tr>
              <tr valign="top">
                <td>39</td>
                <td>Kojima et al [<xref ref-type="bibr" rid="ref62">62</xref>], 2011, Japan</td>
                <td>Physiotherapy and occupational therapy (N=41)</td>
                <td>Pre-post test, 1-group design: questionnaire</td>
                <td>Ease of use; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>40</td>
                <td>Koulias et al [<xref ref-type="bibr" rid="ref63">63</xref>], 2012, Australia</td>
                <td>Medicine (N=171)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>41</td>
                <td>Kow et al [<xref ref-type="bibr" rid="ref64">64</xref>], 2016, Singapore</td>
                <td>Medicine (N=221)</td>
                <td>Pre-post test, 1-group design: questionnaire</td>
                <td>Learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>42</td>
                <td>Kurniawan and Witjaksono [<xref ref-type="bibr" rid="ref65">65</xref>], 2018, Indonesia</td>
                <td>Medicine (N=30)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>43A</td>
                <td>Lefroy et al [<xref ref-type="bibr" rid="ref66">66</xref>], 2017, United Kingdom</td>
                <td>Medicine (N=21)</td>
                <td>Qualitative methods: focus groups; data from app</td>
                <td>Context of use; frequency of use; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>43B</td>
                <td>Lefroy et al [<xref ref-type="bibr" rid="ref66">66</xref>], 2017, United Kingdom</td>
                <td>Medicine (N=405)</td>
                <td>Quantitative methods: data from app</td>
                <td>Context of use; frequency of use; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>44</td>
                <td>Li et al [<xref ref-type="bibr" rid="ref67">67</xref>], 2019, Taiwan</td>
                <td>Health care (N=70)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire<sup>b</sup></td>
                <td>Ease of use; usefulness</td>
              </tr>
              <tr valign="top">
                <td>45</td>
                <td>Lin and Lin [<xref ref-type="bibr" rid="ref68">68</xref>], 2016, Taiwan</td>
                <td>Nursing (N=36)</td>
                <td>Pre-post test, nonrandomized control group design: questionnaire</td>
                <td>Cognitive load; ease of use; learnability; learning performance; usefulness</td>
              </tr>
              <tr valign="top">
                <td>46</td>
                <td>Lone et al [<xref ref-type="bibr" rid="ref69">69</xref>], 2019, Ireland</td>
                <td>Dentist (N=59)</td>
                <td>Randomized controlled trial: questionnaire; task and knowledge performance</td>
                <td>Ease of use; learnability; learning performance; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>47A</td>
                <td>Long et al [<xref ref-type="bibr" rid="ref70">70</xref>], 2016, United States</td>
                <td>Nursing (N=158)</td>
                <td>Pre-post test, 1-group design: questionnaire; data from app</td>
                <td>Ease of use; efficiency; learnability; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>47B</td>
                <td>Long et al [<xref ref-type="bibr" rid="ref70">70</xref>], 2016, United States</td>
                <td>Health science (N=159)</td>
                <td>Randomized controlled trial: questionnaire; data from app</td>
                <td>Ease of use; efficiency; learnability; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>48</td>
                <td>Longmuir [<xref ref-type="bibr" rid="ref71">71</xref>], 2014, United States</td>
                <td>Medicine (N=56)</td>
                <td>Posttest 1-group design: questionnaire; data from app</td>
                <td>Efficiency; learnability; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>49</td>
                <td>López et al [<xref ref-type="bibr" rid="ref72">72</xref>], 2016, Spain</td>
                <td>Medicine (N=67)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Context of use; ease of use; errors; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>50</td>
                <td>Lozano-Lozano et al [<xref ref-type="bibr" rid="ref73">73</xref>], 2020, Spain</td>
                <td>Physiotherapy (N=110)</td>
                <td>Randomized controlled trial: questionnaire; task and knowledge performance</td>
                <td>Learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>51</td>
                <td>Lucas et al [<xref ref-type="bibr" rid="ref74">74</xref>], 2019, Australia</td>
                <td>Pharmacy (N=39)</td>
                <td>Pre-post test, 1-group design: questionnaire; task and knowledge performance</td>
                <td>Satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>52</td>
                <td>Mathew et al [<xref ref-type="bibr" rid="ref75">75</xref>], 2014, Canada</td>
                <td>Medicine (N=5)</td>
                <td>Think-aloud methods: questionnaire<sup>b</sup>; interviews; task and knowledge performance</td>
                <td>Learnability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>53</td>
                <td>McClure [<xref ref-type="bibr" rid="ref76">76</xref>], 2019, United States</td>
                <td>Nursing (N=16)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Learnability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>54</td>
                <td>McDonald et al [<xref ref-type="bibr" rid="ref77">77</xref>], 2018, Canada</td>
                <td>Medicine (N=20)</td>
                <td>Pre-post test, 1-group design: questionnaire; data from app</td>
                <td>Effectiveness; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>55</td>
                <td>McLean et al [<xref ref-type="bibr" rid="ref78">78</xref>], 2014, Australia</td>
                <td>Medicine (N=58)</td>
                <td>Mixed methods: questionnaire; focus groups; interviews</td>
                <td>Satisfaction</td>
              </tr>
              <tr valign="top">
                <td>56</td>
                <td>McMullan [<xref ref-type="bibr" rid="ref79">79</xref>], 2018, United Kingdom</td>
                <td>Health science (N=60)</td>
                <td>Pre-post test, 1-group design: questionnaire</td>
                <td>Learning performance; navigation; satisfaction; usefulness; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>57</td>
                <td>Mendez-Lopez et al [<xref ref-type="bibr" rid="ref80">80</xref>], 2021, Spain</td>
                <td>Psychology (N=67)</td>
                <td>Pre-post test, 1-group design: questionnaire; task and knowledge performance</td>
                <td>Cognitive load; ease of use; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>58</td>
                <td>Meruvia-Pastor et al [<xref ref-type="bibr" rid="ref81">81</xref>], 2016, Canada</td>
                <td>Nursing (N=10)</td>
                <td>Pre-post test, 1-group design: questionnaire; task and knowledge performance</td>
                <td>Ease of use; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>59</td>
                <td>Mettiäinen [<xref ref-type="bibr" rid="ref82">82</xref>], 2015, Finland</td>
                <td>Nursing (N=121)</td>
                <td>Mixed methods: questionnaire; focus groups</td>
                <td>Ease of use; usefulness</td>
              </tr>
              <tr valign="top">
                <td>60</td>
                <td>Milner et al [<xref ref-type="bibr" rid="ref83">83</xref>], 2020, United States</td>
                <td>Medicine and nursing (N=66)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>61</td>
                <td>Mladenovic et al [<xref ref-type="bibr" rid="ref84">84</xref>], 2021, Serbia</td>
                <td>Dentist (N=56)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Context of use; ease of use; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>62</td>
                <td>Morris and Maynard [<xref ref-type="bibr" rid="ref85">85</xref>], 2010, United Kingdom</td>
                <td>Physiotherapy and nursing (N=19)</td>
                <td>Pre-post test, 1-group design: questionnaire</td>
                <td>Context of use; ease of use; navigation; operational usability; usefulness</td>
              </tr>
              <tr valign="top">
                <td>63A</td>
                <td>Nabhani et al [<xref ref-type="bibr" rid="ref86">86</xref>], 2020, United Kingdom</td>
                <td>Pharmacy (N=56)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; learnability; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>63B</td>
                <td>Nabhani et al [<xref ref-type="bibr" rid="ref86">86</xref>],   <break/>  
             2020, United Kingdom</td>
                <td>Pharmacy (N=152)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; learnability; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>63C</td>
                <td>Nabhani et al [<xref ref-type="bibr" rid="ref86">86</xref>],   <break/>  
             2020, United Kingdom</td>
                <td>Pharmacy (N=33)</td>
                <td>Posttest 1-group design: task and knowledge performance</td>
                <td>Ease of use; learnability; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>64A</td>
                <td>Noguera et al [<xref ref-type="bibr" rid="ref87">87</xref>], 2013, Spain</td>
                <td>Physiotherapy (N=84)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>64B</td>
                <td>Noguera et al [<xref ref-type="bibr" rid="ref87">87</xref>], 2013, Spain</td>
                <td>Physiotherapy (N=76)</td>
                <td>Randomized controlled trial: questionnaire</td>
                <td>Learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>65</td>
                <td>O’Connell et al [<xref ref-type="bibr" rid="ref88">88</xref>], 2016, Ireland</td>
                <td>Medicine, nursing, and pharmacy (N=89)</td>
                <td>Randomized controlled trial: questionnaire<sup>b</sup></td>
                <td>Ease of use; learning performance; operational usability; satisfaction; simplicity</td>
              </tr>
              <tr valign="top">
                <td>66</td>
                <td>Oliveira et al [<xref ref-type="bibr" rid="ref89">89</xref>], 2019, Brazil</td>
                <td>Medicine (N=110)</td>
                <td>Randomized controlled trial: questionnaire; task and knowledge performance</td>
                <td>Frequency of use; learning performance; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>67</td>
                <td>Orjuela et al [<xref ref-type="bibr" rid="ref90">90</xref>], 2015, Colombia</td>
                <td>Medicine (N=22)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>68</td>
                <td>Page et al [<xref ref-type="bibr" rid="ref91">91</xref>], 2016, United States</td>
                <td>Medicine (N=356)</td>
                <td>Mixed methods: questionnaire; interviews</td>
                <td>Context of use; efficiency; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>69</td>
                <td>Paradis et al [<xref ref-type="bibr" rid="ref92">92</xref>], 2018, Canada</td>
                <td>Medicine and nursing (N=108)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Ease of use; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>70</td>
                <td>Pereira et al [<xref ref-type="bibr" rid="ref93">93</xref>], 2017, Brazil</td>
                <td>Medicine (N=20)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Ease of use; learnability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>71</td>
                <td>Pereira et al [<xref ref-type="bibr" rid="ref94">94</xref>], 2019, Brazil</td>
                <td>Nursing (N=60)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>72A</td>
                <td>Pinto et al [<xref ref-type="bibr" rid="ref95">95</xref>], 2008, Brazil</td>
                <td>Biomedical informatics (N=5)</td>
                <td>Qualitative methods: observations; task and knowledge performance</td>
                <td>Efficiency; errors; learnability; learning performance; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>72B</td>
                <td>Pinto et al [<xref ref-type="bibr" rid="ref95">95</xref>], 2008, Brazil</td>
                <td>Medicine (N=not clear)</td>
                <td>Posttest nonrandomized control group design: questionnaire</td>
                <td>Efficiency; errors; learnability; learning performance; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>73</td>
                <td>Quattromani et al [<xref ref-type="bibr" rid="ref96">96</xref>], 2018, United States</td>
                <td>Nursing (N=181)</td>
                <td>Randomized controlled trial: questionnaire<sup>b</sup></td>
                <td>Learnability; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>74</td>
                <td>Robertson and Fowler [<xref ref-type="bibr" rid="ref97">97</xref>], 2017, United States</td>
                <td>Medicine (N=18)</td>
                <td>Qualitative methods: focus groups</td>
                <td>Satisfaction</td>
              </tr>
              <tr valign="top">
                <td>75A</td>
                <td>Romero et al [<xref ref-type="bibr" rid="ref98">98</xref>], 2021, Germany</td>
                <td>Medicine (N=22)</td>
                <td>Think-aloud methods: questionnaire; interviews; task and knowledge performance</td>
                <td>Effectiveness; efficiency; errors; navigation; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>75B</td>
                <td>Romero et al [<xref ref-type="bibr" rid="ref98">98</xref>], 2021, Germany</td>
                <td>Medicine (N=22)</td>
                <td>Posttest 1-group design: questionnaire<sup>b</sup></td>
                <td>Learnability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>75C</td>
                <td>Romero et al [<xref ref-type="bibr" rid="ref98">98</xref>], 2021, Germany</td>
                <td>Medicine (N=736)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Frequency of use; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>76</td>
                <td>Salem et al [<xref ref-type="bibr" rid="ref99">99</xref>], 2020, Australia</td>
                <td>Pharmacy (N=33)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Operational usability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>77</td>
                <td>San Martín-Rodríguezet al [<xref ref-type="bibr" rid="ref100">100</xref>], 2020, Spain</td>
                <td>Nursing (N=77)</td>
                <td>Posttest 1-group design: questionnaire; task and knowledge performance</td>
                <td>Learning performance; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>78</td>
                <td>Schnepp and Rogers [<xref ref-type="bibr" rid="ref101">101</xref>], 2017, United States</td>
                <td>Not clear (N=72)</td>
                <td>Think-aloud methods: questionnaire<sup>b</sup>; interviews; task and knowledge performance</td>
                <td>Learnability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>79</td>
                <td>Smith et al [<xref ref-type="bibr" rid="ref102">102</xref>], 2016, United Kingdom</td>
                <td>Medicine and nursing (N=74)</td>
                <td>Mixed methods: questionnaire; focus groups</td>
                <td>Navigation; operational usability; satisfaction; user-friendliness</td>
              </tr>
              <tr valign="top">
                <td>80</td>
                <td>Strandell-Laine et al [<xref ref-type="bibr" rid="ref103">103</xref>], 2019, Finland</td>
                <td>Nursing (N=52)</td>
                <td>Mixed methods: questionnaire<sup>b</sup>; written qualitative responses</td>
                <td>Learnability; operational usability; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>81</td>
                <td>Strayer et al [<xref ref-type="bibr" rid="ref104">104</xref>], 2010, United States</td>
                <td>Medicine (N=122)</td>
                <td>Mixed methods: questionnaire; focus groups</td>
                <td>Context of use; learnability; learning performance; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>82</td>
                <td>Taylor et al [<xref ref-type="bibr" rid="ref105">105</xref>], 2010, United Kingdom</td>
                <td>A total of 8 different health care educations (N=79)</td>
                <td>Qualitative methods: focus groups; written qualitative reflections</td>
                <td>Context of use; learnability</td>
              </tr>
              <tr valign="top">
                <td>83</td>
                <td>Toh et al [<xref ref-type="bibr" rid="ref106">106</xref>], 2014, Singapore</td>
                <td>Pharmacy (N=31)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Ease of use; learnability; navigation; usefulness</td>
              </tr>
              <tr valign="top">
                <td>84</td>
                <td>Tsopra et al [<xref ref-type="bibr" rid="ref107">107</xref>], 2020, France</td>
                <td>Medicine (N=57)</td>
                <td>Mixed methods: questionnaire; focus groups</td>
                <td>Ease of use; operational usability; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>85</td>
                <td>Wu [<xref ref-type="bibr" rid="ref108">108</xref>], 2014, Taiwan</td>
                <td>Nursing (N=36)</td>
                <td>Mixed methods: questionnaire; interviews</td>
                <td>Cognitive load; effectiveness; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>86</td>
                <td>Wyatt et al [<xref ref-type="bibr" rid="ref109">109</xref>], 2012, United States</td>
                <td>Nursing (N=12)</td>
                <td>Qualitative methods: focus groups</td>
                <td>Ease of use; efficiency; errors; learnability; memorability; navigation; satisfaction</td>
              </tr>
              <tr valign="top">
                <td>87</td>
                <td>Yap [<xref ref-type="bibr" rid="ref110">110</xref>], 2017, Singapore</td>
                <td>Pharmacy (N=123)</td>
                <td>Posttest 1-group design: questionnaire</td>
                <td>Comprehensibility; learning performance; memorability; navigation; satisfaction; usefulness</td>
              </tr>
              <tr valign="top">
                <td>88</td>
                <td>Zhang et al [<xref ref-type="bibr" rid="ref111">111</xref>], 2015, Singapore</td>
                <td>Medicine (N=185)</td>
                <td>Mixed methods: questionnaire; focus groups</td>
                <td>Usefulness</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>Performances measured, comparing paper and app results, quiz results, and exam results.</p>
            </fn>
            <fn id="table2fn2">
              <p><sup>b</sup>Reported use of validated questionnaires.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Usability Evaluation Methods</title>
        <p>The usability evaluation methods found were either inquiry-based or based on user testing. The following inquiry methods were used: 1-group design (46/98, 47%), control group design (12/98, 12%), randomized controlled trials (12/98, 12%), mixed methods (12/98, 12%), and qualitative methods (11/98, 11%). Several studies that applied inquiry-based methods used more than one data collection method, with questionnaires being used most often (80/98, 82%), followed by task and knowledge performance testing (17/98, 17%), focus groups (15/98, 15%), collection of user data from the app (10/98, 10%), interviews (5/98, 5%), written qualitative reflections (4/98, 4%), and observations (3/98, 3%). Additional information can be found in the data extraction sheet (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>). <xref rid="figure2" ref-type="fig">Figure 2</xref> illustrates the frequency of the inquiry-based usability evaluation methods and data collection methods.</p>
        <p>The only user testing methods found were think-aloud methods (5/98, 5%), and 4 (80%) of these studies applied more than one data collection method. The data collection methods used included interviews (4/98, 4%), questionnaires (3/98, 3%), task and knowledge performance (3/98, 3%), focus groups (1/98, 1%), and collection of user data from the app (1/98, 1%).</p>
        <p>A total of 19 studies used a psychometrically tested usability questionnaire, including the SUS, Technology Acceptance Model, Technology Satisfaction Questionnaire, and Technology Readiness Index. SUS [<xref ref-type="bibr" rid="ref112">112</xref>] was used in most (9/98, 9%) of the studies.</p>
        <p>Field testing was the most frequent type of usability experiment, accounting for 72% (71/98) of usability experiments. A total of 22 (22%) studies performed laboratory testing, and 5 (5%) studies did not indicate the type of experiment performed. <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> provides an overview of the type of experiment conducted in each study. The usability testing of the mobile apps took place in a classroom setting (41/98, 42%), in clinical placement (29/98, 30%), during simulation training (14/98, 14%), other (7/98, 7%), or the setting was not specified (5/98, 5%).</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Inquiry usability evaluation methods and data collection methods.</p>
          </caption>
          <graphic xlink:href="mededu_v8i2e38259_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Usability Attributes</title>
        <p>A total of 17 usability attributes have been identified among the included studies. The most frequently identified attributes were satisfaction, usefulness, ease of use, learning performance, and learnability. The least frequent were errors, cognitive load, comprehensibility, memorability, and simplicity. <xref ref-type="table" rid="table3">Table 3</xref> provides an overview of the usability attributes identified in the included studies.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Distribution of usability attributes (n=17) and affiliated reports (N=88).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="190"/>
            <col width="150"/>
            <col width="660"/>
            <thead>
              <tr valign="top">
                <td>Usability attribute</td>
                <td>Distribution, n (%)</td>
                <td>Reports (references)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Satisfaction</td>
                <td>74 (84)</td>
                <td>[<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref86">86</xref>-<xref ref-type="bibr" rid="ref104">104</xref>,<xref ref-type="bibr" rid="ref107">107</xref>-<xref ref-type="bibr" rid="ref110">110</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Usefulness</td>
                <td>51 (58)</td>
                <td>[<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref28">28</xref>-<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref72">72</xref>-<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref79">79</xref>-<xref ref-type="bibr" rid="ref87">87</xref>,<xref ref-type="bibr" rid="ref92">92</xref>,<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref96">96</xref>,<xref ref-type="bibr" rid="ref99">99</xref>,<xref ref-type="bibr" rid="ref104">104</xref>,<xref ref-type="bibr" rid="ref106">106</xref>-<xref ref-type="bibr" rid="ref108">108</xref>,<xref ref-type="bibr" rid="ref110">110</xref>,<xref ref-type="bibr" rid="ref111">111</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Ease of use</td>
                <td>45 (51)</td>
                <td>[<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref84">84</xref>-<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref88">88</xref>,<xref ref-type="bibr" rid="ref90">90</xref>,<xref ref-type="bibr" rid="ref92">92</xref>-<xref ref-type="bibr" rid="ref94">94</xref>,<xref ref-type="bibr" rid="ref106">106</xref>,<xref ref-type="bibr" rid="ref107">107</xref>,<xref ref-type="bibr" rid="ref109">109</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Learning performance</td>
                <td>33 (38)</td>
                <td>[<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref68">68</xref>-<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref79">79</xref>-<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref86">86</xref>-<xref ref-type="bibr" rid="ref89">89</xref>,<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref96">96</xref>,<xref ref-type="bibr" rid="ref100">100</xref>,<xref ref-type="bibr" rid="ref104">104</xref>,<xref ref-type="bibr" rid="ref110">110</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Learnability</td>
                <td>23 (26)</td>
                <td>[<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref68">68</xref>-<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref96">96</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref101">101</xref>,<xref ref-type="bibr" rid="ref103">103</xref>-<xref ref-type="bibr" rid="ref106">106</xref>,<xref ref-type="bibr" rid="ref109">109</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Operational usability</td>
                <td>19 (22)</td>
                <td>[<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref88">88</xref>,<xref ref-type="bibr" rid="ref90">90</xref>,<xref ref-type="bibr" rid="ref94">94</xref>,<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref99">99</xref>-<xref ref-type="bibr" rid="ref101">101</xref>,<xref ref-type="bibr" rid="ref103">103</xref>,<xref ref-type="bibr" rid="ref107">107</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Context of use</td>
                <td>14 (16)</td>
                <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref91">91</xref>,<xref ref-type="bibr" rid="ref104">104</xref>,<xref ref-type="bibr" rid="ref105">105</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Navigation</td>
                <td>12 (14)</td>
                <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref102">102</xref>,<xref ref-type="bibr" rid="ref106">106</xref>,<xref ref-type="bibr" rid="ref109">109</xref>,<xref ref-type="bibr" rid="ref110">110</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Efficiency</td>
                <td>11 (13)</td>
                <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref91">91</xref>,<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref109">109</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Effectiveness</td>
                <td>10 (11)</td>
                <td>[<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref108">108</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Frequency of use</td>
                <td>10 (11)</td>
                <td>[<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref89">89</xref>,<xref ref-type="bibr" rid="ref98">98</xref>]</td>
              </tr>
              <tr valign="top">
                <td>User-friendliness</td>
                <td>7 (8)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref102">102</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Errors</td>
                <td>5 (6)</td>
                <td>[<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref109">109</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Cognitive load</td>
                <td>3 (3)</td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref108">108</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Comprehensibility</td>
                <td>2 (2)</td>
                <td>[<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref110">110</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Memorability</td>
                <td>2 (2)</td>
                <td>[<xref ref-type="bibr" rid="ref109">109</xref>,<xref ref-type="bibr" rid="ref110">110</xref>]</td>
              </tr>
              <tr valign="top">
                <td>Simplicity</td>
                <td>2 (2)</td>
                <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref88">88</xref>]</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This scoping review sought to identify the usability methods and attributes reported in usability studies of mobile apps for health care education. A total of 88 articles, with a total of 98 studies reported in these 88 articles, were included in this review. Our findings indicate a steady increase in publications from 2014, with studies being published in 22 different countries. Field testing was used more frequently than laboratory testing. Furthermore, the usability evaluation methods applied were either inquiry-based or based on user testing. Most of the inquiry-based methods were experiments that used questionnaires as a data collection method, and all of the studies with user testing methods applied think-aloud methods. Satisfaction, usefulness, ease of use, learning performance, and learnability were the most frequently identified usability attributes.</p>
      </sec>
      <sec>
        <title>Comparison With Prior Work</title>
        <sec>
          <title>Usability Evaluation Methods</title>
          <p>The studies included in this scoping review mainly applied inquiry-based methods, primarily the collection of self-reported data through questionnaires. This is congruent with the results of Weichbroth [<xref ref-type="bibr" rid="ref10">10</xref>], in which controlled observations and surveys were the most frequently applied methods. Asking users to respond to a usability questionnaire may provide relevant and valuable information. Among the 83 studies that used questionnaires in our review, only 19 (23%) used a psychometrically tested usability questionnaire; of these, the SUS questionnaire [<xref ref-type="bibr" rid="ref112">112</xref>] was used most frequently. In line with the review on usability questionnaires [<xref ref-type="bibr" rid="ref12">12</xref>], we recommend using a psychometrically tested usability questionnaire to support the advancement of usability science. As questionnaires address only certain usability attributes, mainly learnability, efficiency, and satisfaction [<xref ref-type="bibr" rid="ref12">12</xref>], it would be helpful to also include additional methods, such as interviews or mixed methods, and to incorporate additional open-ended questions when using questionnaires.</p>
          <p>Furthermore, the application of usability evaluation methods other than inquiry methods, such as user testing methods and inspection methods [<xref ref-type="bibr" rid="ref10">10</xref>], could be beneficial and lead to more objective measures of app usability. Among other things, subjective data are collected via self-reported questionnaires, and objective data are collected based on task completion rates [<xref ref-type="bibr" rid="ref40">40</xref>]. For example, in one of the included studies, the participants reported that the usability of the app was satisfactory by subjective measures, but the participants did not use the app [<xref ref-type="bibr" rid="ref75">75</xref>]. Another study reported a lack of coherence between subjective and objective data; thus, these results indicate the importance of not relying solely on subjective measures of usability [<xref ref-type="bibr" rid="ref40">40</xref>]. Therefore, it is suggested that various usability evaluation methods, including subjective and objective usability measures, are used in future usability studies.</p>
          <p>Our review found that most of the included studies in health care education (71/98, 72%) performed field testing, whereas previous literature suggests that usability experiments in other fields are more often conducted in a laboratory [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref113">113</xref>]. For instance, Kumar and Mohite [<xref ref-type="bibr" rid="ref1">1</xref>] found that 73% of the studies included in their review of mobile learning apps used laboratory testing. Mobile apps in health care education have been developed to support students’ learning, on-campus and during clinical placement, in various settings and on the move. Accordingly, it is especially important to test how the apps are perceived in specific environments [<xref ref-type="bibr" rid="ref5">5</xref>]; hence, field testing is required. However, many usability issues can be discovered in a laboratory. Particularly in the early phases of app development, testing an app with several participants in a laboratory may make it more feasible to test and improve the app [<xref ref-type="bibr" rid="ref8">8</xref>]. Usability testing in a laboratory can provide rapid feedback on usability issues, which can then be addressed before testing the app in a real-world environment. Therefore, it may be beneficial to conduct small-scale laboratory testing before field testing.</p>
        </sec>
        <sec>
          <title>Usability Attributes</title>
          <p>Previous systematic reviews of mobile apps in general identified satisfaction, efficiency, and effectiveness as the most common usability attributes [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. In this review, efficiency and effectiveness were explored to a limited extent, whereas satisfaction, usefulness, and ease of use were the most frequently identified usability attributes. Our results coincide with those from a previous review on the usability of mobile learning apps [<xref ref-type="bibr" rid="ref1">1</xref>], possibly because satisfaction, usefulness, and ease of use are usability attributes of particular importance when examining mobile learning apps.</p>
          <p>Learning performance was assessed frequently in the included studies. For ensuring that apps are valuable in a given learning context, it is relevant to test additional usability attributes such as cognitive load [<xref ref-type="bibr" rid="ref9">9</xref>]. However, few studies included in our review examined cognitive load [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref108">108</xref>]. Mobile apps are often used in an environment with multiple distractions, which may contribute to an increased cognitive load [<xref ref-type="bibr" rid="ref5">5</xref>], affecting the learning performance. Testing both learning performance and app users’ cognitive load may improve the understanding of the app’s usability.</p>
          <p>We found that several of the included studies did not use terminology from usability literature to describe which usability attributes they were testing. For instance, studies that tested satisfaction often used words such as “likes and dislikes” and “recommend use to others” and did not specify that they tested the usability attribute satisfaction. Specifying which usability attributes are investigated will be important when performing a usability study of mobile apps, as this will influence transparency and enable comparison between different studies. In addition, evaluating a wider range of usability attributes may enable researchers to expand their perspective regarding the app’s usability problems and ensure quicker improvement of the app. Defining and presenting different usability attributes in a reporting guideline can assist in deciding on and reporting relevant usability attributes. As such, a reporting guideline would be beneficial for researchers planning and conducting usability studies, a point that is also supported by the systematic review conducted by Kumar and Mohite [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Future Directions</title>
        <p>Combining different usability evaluation methods that incorporate both subjective and objective usability measures can add various and important perspectives when developing apps. In future studies, it would be advantageous to use psychometrically tested usability questionnaires to support the advancement of the usability science. In addition, developers of mobile apps should determine which usability attributes are relevant before conducting usability studies (eg, by registering a protocol). Incorporating these perspectives into the development of a reporting guideline would be beneficial to future usability studies.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>First, the search strategy was designed in collaboration with a research librarian and peer reviewed by another research librarian and included 10 databases and other sources. This broad search strategy resulted in a high number of references, which may be associated with a lower level of precision. To ensure the retrieval of all potentially pertinent articles, two of the authors independently screened titles and abstracts; studies deemed eligible by one of the authors were included for full-text screening.</p>
        <p>Second, the full-text evaluation was challenging because the term <italic>usability</italic> has multiple meanings that do not always relate to usability testing. For instance, the term was used when testing students’ experience of a commercially developed app but not in connection with the app’s further development. In addition, many studies did not explicitly state that a mobile app was being investigated, which also created a challenge when deciding whether they satisfied the eligibility criteria. Nevertheless, reading the full-text articles independently by 2 reviewers and solving disagreements through consensus-based discussions ensured the inclusion of relevant articles.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This scoping review was performed to provide an overview of the usability methods used and the attributes identified in usability studies of mobile apps in health care education. Experimental designs were commonly used to evaluate usability and most studies used field testing. Questionnaires were frequently used for data collection, although few studies used psychometrically tested questionnaires. Usability attributes identified most often were satisfaction, usefulness, and ease of use. The results indicate that combining different usability evaluation methods, incorporating both subjective and objective usability measures, and specifying which usability attributes to test seem advantageous. The results can support the planning and conduct of future usability studies of the advancement of learning apps in health care education.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist for reporting scoping reviews.</p>
        <media xlink:href="mededu_v8i2e38259_app1.docx" xlink:title="DOCX File , 107 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>The search strategies for the 10 databases.</p>
        <media xlink:href="mededu_v8i2e38259_app2.docx" xlink:title="DOCX File , 84 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Data extraction sheet.</p>
        <media xlink:href="mededu_v8i2e38259_app3.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 156 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">SUS</term>
          <def>
            <p>System Usability Scale</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>The research library at Western Norway University of Applied Sciences provided valuable assistance in developing and performing the search strategy for this scoping review. Gunhild Austrheim, a research librarian, provided substantial guidance in the planning and performance of the database searches. Marianne Nesbjørg Tvedt peer reviewed the search string. Malik Beglerovic also assisted with database searches. The authors would also like to thank Ane Kjellaug Brekke Gjerland for assessing the data extraction sheet.</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>SGJ, LL, DC, and NRO proposed the idea for this review. SGJ, DC, and NRO contributed to the screening of titles and abstracts, and SGJ and TP decided on eligibility based on full-text examinations. SGJ extracted data from the included studies. SGJ, TP, LL, DC, and NRO contributed to the drafts of the manuscript, and all authors approved the final version for publication.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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